Department of Biochemistry and Forensic Sciences, School of Chemical and Biochemical Sciences, C. K. Tedam University of Technology and Applied Sciences, Navrongo, Ghana.
Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, University for Development Studies, Tamale, Ghana.
BMC Res Notes. 2023 May 20;16(1):83. doi: 10.1186/s13104-023-06354-7.
The synergism among extracts of Senna alata, Ricinus communis, and Lannea barteri, and their anti-infective activities were investigated. The data collected for the antimicrobial activity of the extracts combinations were interpreted to be one of the following categories: synergy; indifferent; additive; or antagonistic. The interpretation was made based on the fractional inhibitory concentration index (FICI) results. FICI of ≤ 0.5 indicates synergism, > 0.5 to 1 indicates additive effects, > 1 to ≤ 4 indifference, and > 4 is considered to be antagonism.
Compared with the data of the individual extracts, the MIC values of the extract-extract combinations against all strains of the tested microorganisms were significantly lower, ranging from 0.97 to 1.17, 0.97 to 4.69, 0.50 to 1.17, 1.17 to 3.12 and 2.34 to 4.69 mg/mL for Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia and Candida albicans respectively. L. bateri aqueous-S. alata ethanol extracts and S. alata aqueous-R. cummunis ethanol extracts combinations showed a synergy effect against all the test microorganisms. The other combinations exhibited at least one additive effect. Neither antagonism nor indifference activity was observed. This study validates the relevance of combining these plants in treating infections by traditional medicine practitioners.
研究了番泻叶、蓖麻和伯乐树提取物的协同作用及其抗感染活性。对提取物组合的抗菌活性数据的解释为以下类别之一：协同作用；无差异；相加；或拮抗。根据部分抑制浓度指数（FICI）的结果进行解释。FICI≤0.5 表示协同作用，0.5 至 1 表示相加作用，1 至≤4 表示无差异，4 表示拮抗作用。
与单个提取物的数据相比，提取物-提取物组合对所有测试微生物株的 MIC 值明显更低，范围为 0.97 至 1.17、0.97 至 4.69、0.50 至 1.17、1.17 至 3.12 和 2.34 至 4.69mg/mL，分别为大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌、肺炎克雷伯菌和白色念珠菌。伯乐树水-S. alata 乙醇提取物和 S. alata 水-R. cummunis 乙醇提取物组合对所有测试微生物均表现出协同作用。其他组合至少表现出一种相加作用。未观察到拮抗或无差异活性。这项研究验证了传统医学从业者联合使用这些植物治疗感染的相关性。
