游离轻链作为鞘内合成的可靠生物标志物在中枢神经系统炎症性疾病诊断中的应用。
Free light chains as a reliable biomarker of intrathecal synthesis in the diagnosis of CNS inflammatory diseases.
机构信息
Department of Laboratory Medicine, Papa Giovanni XXIII Hospital, Piazza OMS, 1, 24127 Bergamo, Italy.
Department of Laboratory Medicine, Papa Giovanni XXIII Hospital, Piazza OMS, 1, 24127 Bergamo, Italy.
出版信息
J Neuroimmunol. 2023 Jun 15;379:578091. doi: 10.1016/j.jneuroim.2023.578091. Epub 2023 Apr 22.
OBJECTIVE
To address the diagnostic performances of cerebrospinal fluid (CSF) free light chains (FLC) measurements compared to oligoclonal bands (OCB) to support multiple sclerosis (MS) diagnosis.
RESULTS
kFLC index showed the highest diagnostic accuracy to detect MS patients with the highest AUC compared to OCB, IgG index, IF kFLC R, kFLC H, λFLC index and IF λFLC.
CONCLUSIONS
FLC indices are biomarkers of intrathecal Immunoglobulin synthesis and central nervous system (CNS) inflammation. kFLC index can discriminate between MS and other CNS inflammatory disorders, while λFLC index is less informative for MS but can play a role to support the diagnosis of other inflammatory CNS disorders.
目的
评估脑脊液（CSF）游离轻链（FLC）测量与寡克隆带（OCB）相比在支持多发性硬化症（MS）诊断中的诊断性能。
结果
与 OCB、IgG 指数、IF kFLC R、kFLC H、λFLC 指数和 IF λFLC 相比，kFLC 指数显示出最高的诊断准确性，可用于检测 MS 患者，具有最高的 AUC。
结论
FLC 指数是鞘内免疫球蛋白合成和中枢神经系统（CNS）炎症的生物标志物。kFLC 指数可区分 MS 和其他 CNS 炎症性疾病，而 λFLC 指数对 MS 的信息较少，但可在支持其他炎症性 CNS 疾病的诊断中发挥作用。
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