Faculty of Medicine, University of Surabaya, Surabaya 60292, Indonesia.
Faculty of Medicine, University of Surabaya, Surabaya 60292, Indonesia; Magister in Biomedical Science Program, Faculty of Medicine Universitas Brawijaya, Malang 65112, Indonesia.
Clin Chim Acta. 2023 Jun 1;546:117389. doi: 10.1016/j.cca.2023.117389. Epub 2023 May 19.
Alzheimer's disease (AD) is on the rise worldwide. Generally, AD is considered neurodegenerative when the production and clearance of amyloid-β (Aβ) are imbalanced. Recent research on genome-wide association studies (GWAS) has been explosive; GWAS indicates a relationship between single nucleotide polymorphism (SNP) and AD. GWAS also reveals ethnic differences between Caucasians and Asians. This indicates that pathogenesis between ethnic groups is distinct. According to current scientific knowledge, AD is a disease with a complex pathogenesis that includes impaired neuronal cholesterol regulation, immunity regulation, neurotransmitters regulation, Aβ clearance, Aβ production, and vascular regulation. Here, we demonstrate the pathogenesis of AD in an Asian population and the SNP risk of AD for future AD screening before onset. According to our knowledge, this is the first review of Alzheimer's disease to demonstrate the pathogenesis of AD based on SNP in an Asian population.
阿尔茨海默病（AD）在全球范围内呈上升趋势。一般来说，当淀粉样蛋白-β（Aβ）的产生和清除失衡时，AD 被认为是神经退行性的。最近对全基因组关联研究（GWAS）的研究呈爆炸式增长；GWAS 表明单核苷酸多态性（SNP）与 AD 之间存在关系。GWAS 还揭示了白种人和亚洲人之间的种族差异。这表明不同种族之间的发病机制不同。根据目前的科学知识，AD 是一种具有复杂发病机制的疾病，包括神经元胆固醇调节、免疫调节、神经递质调节、Aβ清除、Aβ产生和血管调节受损。在这里，我们展示了亚洲人群中 AD 的发病机制以及 AD 的 SNP 风险，以便在发病前进行 AD 筛查。据我们所知，这是第一篇基于亚洲人群中 SNP 来展示 AD 发病机制的 AD 综述。
