Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamilnadu, 603103, India.
PG & Research Department of Zoology and Biotechnology, AVVM Sri Pushpam College, Poondi, Thanjavur, 613 503, Tamil Nadu, India.
J Egypt Natl Canc Inst. 2023 May 22;35(1):15. doi: 10.1186/s43046-023-00177-0.
A malignancy of the endocrine system, one of the most common types, is thyroid cancer. It is proven that children who receive radiation treatment for leukemia or lymphoma are at a heightened risk of thyroid cancer due to low-dose radiation exposure throughout childhood. Several factors can increase the risk of thyroid cancer (ThyCa), such as chromosomal and genetic mutations, iodine intake, TSH levels, autoimmune thyroid disorders, estrogen, obesity, lifestyle changes, and environmental contaminants.
The study aimed to identify a specific gene as an essential candidate for thyroid cancer progression. We might be able to focus on developing a better understanding of how thyroid cancer is inherited.
The review article uses electronic databases such as PubMed, Google Scholar, Ovid MEDLINE, Embase, and Cochrane Central. The most frequently associated genes with thyroid cancer found on PubMed were BAX, XRCC1, XRCC3, XPO5, IL-10, BRAF, RET, and K-RAS. To perform an electronic literature search, genes derived from DisGeNET: a database of gene-disease associations, including PRKAR1A, BRAF, RET, NRAS, and KRAS, are used.
Examining the genetics of thyroid cancer explicitly emphasizes the primary genes associated with the pathophysiology of young and older people with thyroid cancer. Developing such gene investigations at the beginning of the thyroid cancer development process can identify better outcomes and the most aggressive thyroid cancers.
内分泌系统的恶性肿瘤是最常见的肿瘤类型之一，即甲状腺癌。已证实，因儿童期全身接受低剂量辐射，曾因白血病或淋巴瘤接受过放射治疗的儿童，患甲状腺癌的风险会增加。有几个因素会增加患甲状腺癌（ThyCa）的风险，如染色体和基因突变、碘摄入、TSH 水平、自身免疫性甲状腺疾病、雌激素、肥胖、生活方式改变和环境污染物。
本研究旨在确定一个特定基因作为甲状腺癌进展的重要候选基因。我们或许能够专注于研究如何遗传甲状腺癌。
综述文章使用了电子数据库，如 PubMed、Google Scholar、Ovid MEDLINE、Embase 和 Cochrane Central。在 PubMed 上发现与甲状腺癌关联最频繁的基因有 BAX、XRCC1、XRCC3、XPO5、IL-10、BRAF、RET 和 K-RAS。为了进行电子文献检索，还使用了 DisGeNET 中的基因，该数据库是一个基因-疾病关联数据库，包括 PRKAR1A、BRAF、RET、NRAS 和 KRAS。
明确研究甲状腺癌的遗传学，重点强调了与年轻和老年甲状腺癌患者病理生理学相关的主要基因。在甲状腺癌发展过程的早期进行此类基因研究，可以确定更好的结果和侵袭性更强的甲状腺癌。
