Department of Dermatology, STDs and Andrology, Faculty of Medicine, Minia University, Minia, Egypt.
Int J Dermatol. 2023 Jul;62(7):888-894. doi: 10.1111/ijd.16717. Epub 2023 May 22.
Facial erythema in rosacea is a troublesome embarrassing presentation with limited options of treatment. Daily brimonidine gel was shown to be an effective modality of treatment. Being unavailable in Egypt and the scarcity of objective evaluation of its therapeutic effect motivated the search for other alternatives.
To evaluate the use and effectiveness of topical brimonidine eye drops for the management of facial erythema in rosacea with the aid of objective assessment.
The study was conducted on 10 rosacea patients presented with facial erythema. Brimonidine tartrate eye drops 0.2% were applied twice daily for 3 months on areas of red facial skin. Punch biopsies were obtained before and after 3 months of treatment. Routine hematoxylin and eosin (H&E) staining as well as CD34 immunohistochemical staining were performed for all biopsies. Sections were examined to detect the changes in the count and the surface area of blood vessels.
Evaluation of clinical results showed good improvement of facial redness at the end of treatment (55-75%). Only 10% of subjects expressed rebound erythema. H&E and CD34 stained sections showed an increased count of dilated dermal blood vessels, which decreased significantly after treatment in count and surface area (P = 0.005, and P = 0.004, respectively).
Topical brimonidine eye drops proved to be effective in managing facial erythema in rosacea, providing an available and cheaper alternative to brimonidine gel. The study improved the subjective evaluation in the context of objective assessment of treatment efficacy.
酒渣鼻的面部红斑是一种令人困扰且尴尬的表现，治疗方法有限。每日使用苯肾上腺素凝胶已被证明是一种有效的治疗方法。但由于该药在埃及无法获得，且其治疗效果缺乏客观评估，因此需要寻找其他替代方法。
评估使用 0.2%马来酸噻吗洛尔滴眼液治疗酒渣鼻面部红斑的效果，并通过客观评估来辅助疗效判断。
本研究纳入了 10 名面部红斑的酒渣鼻患者。所有患者均使用 0.2%马来酸噻吗洛尔滴眼液，每日 2 次，涂抹于红斑区域，共治疗 3 个月。在治疗前和治疗 3 个月后，分别采集患者的皮肤活检标本。对所有活检标本进行常规苏木精-伊红（H&E）染色和 CD34 免疫组化染色，以评估血管计数和表面面积的变化。
临床评估结果显示，治疗结束时（55-75%）患者的面部红斑有明显改善。仅有 10%的患者出现红斑反弹。H&E 和 CD34 染色切片显示，扩张的真皮血管计数增加，治疗后计数和表面面积均显著减少（P=0.005 和 P=0.004）。
马来酸噻吗洛尔滴眼液治疗酒渣鼻面部红斑有效，是苯肾上腺素凝胶的一种有效且更经济的替代方法。本研究在治疗效果的客观评估背景下，提高了主观评估的可信度。
