英国当前的肿瘤整形保乳手术实践和提供情况:ANTHEM 全国实践问卷调查结果。

Current practice and provision of oncoplastic breast-conserving surgery in the UK: results of the ANTHEM national practice questionnaire.

机构信息

Bristol Centre for Surgical Research, Population Health Sciences, Bristol Medical School, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.

Nottingham Breast Institute, Nottingham University Hospitals NHS Trust, Hucknall Road, Nottingham, NG5 1PB, UK.

出版信息

Breast Cancer Res Treat. 2023 Jul;200(2):163-170. doi: 10.1007/s10549-023-06924-0. Epub 2023 May 22.

Abstract

PURPOSE

Oncoplastic breast-conserving surgery (OPBCS) may be a better option than mastectomy ± immediate breast reconstruction (IBR) for women with breast cancer but studies directly comparing the techniques are lacking. We surveyed UK breast units to determine the current practice of OPBCS to inform the design of a future comparative study.

METHODS

An electronic survey was developed to explore the current practice of OPBCS. This included the local availability of volume displacement and/or replacement techniques; number of cases performed; contraindications and approach to contralateral symmetrisation. Summary data for each survey item were calculated and overall provision of care examined.

RESULTS

58 UK centres completed the survey, including 43 (74%) stand-alone breast and 15 (26%) combined breast/plastics units. Over 40% of units (n = 24) treated more than 500 cancers/year. Most units offered volume displacement techniques (TMs) (97%). Over two-thirds (n = 39. 67%) of units offered local perforator flaps (LPF). Approximately a half of units (10/19) not performing LPF were planning to introduce them in the next 12-24 months. A third (n = 19, 33%) of units routinely performed simultaneous contralateral symmetrisation mostly with two-surgeon operating. There were limited oncological restrictions to OPBCS with no contraindications for multifocal cancers in most centres; 65% of units (36/55) offered OPBCS for multicentric disease. Extensive DCIS was a contraindication in a minority of units.

CONCLUSIONS

OPBCS is widely available in the UK but contraindications and approaches to contralateral symmetrisation were variable. Work is now needed to prospectively evaluate the outcomes of OPBCS vs mastectomy ± IBR to support informed decision-making.

摘要

目的

对于患有乳腺癌的女性,肿瘤整形保乳手术(oncoplastic breast-conserving surgery,OPBCS)可能优于乳房切除术±即刻乳房重建(immediate breast reconstruction,IBR)。但目前缺乏直接比较这两种技术的研究。我们调查了英国的乳房外科单位,以确定 OPBCS 的当前实践,为未来的比较研究提供信息。

方法

开发了一项电子调查,以探讨 OPBCS 的当前实践。这包括局部容积移位和/或替代技术的可用性;手术例数;禁忌症和对侧对称的方法。对每个调查项目的汇总数据进行计算,并检查整体护理提供情况。

结果

58 家英国中心完成了调查,其中 43 家(74%)为独立的乳房外科中心,15 家(26%)为联合乳房/整形外科中心。超过 40%的单位(n=24)每年治疗超过 500 例癌症。大多数单位提供容积移位技术(TMs)(97%)。超过三分之二的单位(n=39,67%)提供局部穿支皮瓣(LPF)。约有一半的单位(10/19)未行 LPF 计划在未来 12-24 个月内引入。三分之一的单位(n=19,33%)常规进行同期对侧对称手术,大多数采用双外科医生操作。OPBCS 的肿瘤学限制较少,大多数中心没有多灶性癌症的禁忌症;65%的单位(36/55)为多中心疾病提供 OPBCS。少数单位将广泛的 DCIS 视为禁忌症。

结论

OPBCS 在英国广泛应用,但禁忌症和对侧对称的方法存在差异。现在需要进行前瞻性研究,评估 OPBCS 与乳房切除术±IBR 的结果,以支持知情决策。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b0d/10201489/fb613b92f8fd/10549_2023_6924_Fig1_HTML.jpg

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