Sharma Aishwarya, Moon Deborah, Kim Dong Joo
School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA.
Department of Dermatology, University of California, Irvine, CA 92697, USA.
Case Rep Dermatol Med. 2023 May 13;2023:6397272. doi: 10.1155/2023/6397272. eCollection 2023.
Confluent and reticulated papillomatosis (CARP) is a rare keratinization disorder that presents with asymptomatic, reticulated papules coalescing into plaques, which adversely affect, most often, young black persons. Minocycline is considered the drug of choice, but it is not without its host of potential side effects, including drug hypersensitivity, drug-induced lupus/vasculitis/hepatitis, blue-gray skin hyperpigmentation, acute eosinophilic pneumonia, pseudotumor cerebri, and vestibular instability, among others. Alternatively, doxycycline might be considered as another first-line agent for CARP as it can effectively clear lesions while offering a more favorable side effect profile in select patients. Herein, we present a case of CARP successfully resolved with doxycycline after a protracted treatment history of topical and oral antifungal medications for suspected tinea versicolor (TV).
融合性网状乳头瘤病（CARP）是一种罕见的角化异常疾病，表现为无症状的网状丘疹融合成斑块，最常影响年轻黑人。米诺环素被认为是首选药物，但它也有一系列潜在副作用，包括药物过敏、药物性狼疮/血管炎/肝炎、蓝灰色皮肤色素沉着、急性嗜酸性肺炎、假性脑瘤和前庭不稳等。另外，多西环素可被视为CARP的另一种一线药物，因为它能有效清除病变，同时在部分患者中副作用较小。在此，我们报告一例CARP患者，在因疑似花斑癣（TV）接受局部和口服抗真菌药物的长期治疗后，使用多西环素成功治愈。
