Olbrich H M, Lanczos L, Lodemann E, Zerbin D, Engelmeier M P, Nau H E, Schmit-Neuerburg K P
Fortschr Neurol Psychiatr. 1986 Jun;54(6):182-8. doi: 10.1055/s-2007-1001863.
Event-related potential recording (component N1, P2, N2, and P3) and neuropsychological assessment of cognitive impairment were carried out on 15 patients with brain tumour, 15 patients with severe head injury and 24 controls. The tumour and trauma patients had significantly lower psychological test scores, smaller N1 amplitudes and longer N2 and P3 latencies than normals. For the tumour and trauma patients significant correlations were found between N2 and P3 latency and the Mini-Mental State test and memory tests. For individual patients abnormally increased N2 and P3 latency was found to occur in association with abnormally reduced neuropsychological test scores. N2 and P3 latency proved the only electrophysiological variables examined which provided a measure of cerebral functioning correlating with the psychometric variables. N2 and P3 latency may be regarded as a useful diagnostic test for cognitive impairment especially in patients with motor handicaps, to whom neuropsychological tests cannot be administered.
对15例脑肿瘤患者、15例重度颅脑损伤患者和24名对照者进行了事件相关电位记录（成分N1、P2、N2和P3）以及认知障碍的神经心理学评估。肿瘤患者和创伤患者的心理测试得分显著低于正常人，N1波幅更小，N2和P3潜伏期更长。在肿瘤患者和创伤患者中，发现N2和P3潜伏期与简易精神状态测试及记忆测试之间存在显著相关性。对于个体患者，发现N2和P3潜伏期异常增加与神经心理学测试得分异常降低相关。N2和P3潜伏期是所检测的唯一能提供与心理测量变量相关的脑功能指标的电生理变量。N2和P3潜伏期可被视为认知障碍的一种有用诊断测试，尤其是对于无法进行神经心理学测试的运动障碍患者。
