Dorveaux L, Tonkin A
Int J Biomed Comput. 1986 May;18(3-4):261-71. doi: 10.1016/0020-7101(86)90022-x.
An algorithm which models conduction over two conduction pathways through the atrioventricular (AV) node has been derived and tested. Output from the node has been previously related to input, the coupling intervals of extrastimuli introduced during programmed atrial stimulation. An exponential model of conduction in a single pathway was used with the general form: A2 H2 = K1 + K2 exp (-A1 A2/K3) with K1, K2, K3 parameters The algorithm for identification of dual pathways minimised residual sums of squares from two such functions. Potential 'bifurcation' points were selected by significant deviation of the computed single curve of best fit. The algorithm was tested using data obtained during electrophysiology study. Three trials of programmed stimulation were performed in 15 patients after pacing at 100 bpm. Computations using the model suggested single and dual functions (and therefore pathways) respectively in 19 and 25 of 44 trials. An electrophysiologist independently examining the data usually agreed (83% of trials). As the reasons for discordance were minor the model was reasonably verified.
一种模拟通过房室（AV）结的两条传导路径进行传导的算法已被推导并测试。该节点的输出先前已与输入相关，即程控心房刺激期间引入的额外刺激的耦合间期。单一路径传导的指数模型采用一般形式：A2 H2 = K1 + K2 exp (-A1 A2/K3)，其中K1、K2、K3为参数。识别双路径的算法使来自两个此类函数的残差平方和最小化。潜在的“分叉”点通过计算得到的最佳拟合单曲线的显著偏差来选择。该算法使用电生理研究期间获得的数据进行测试。在15名患者以100次/分起搏后进行了三次程控刺激试验。使用该模型的计算分别在44次试验中的19次和25次试验中提示了单函数（以及因此的单路径）和双函数（以及因此的双路径）。一名独立检查数据的电生理学家通常表示同意（83%的试验）。由于不一致的原因较小，该模型得到了合理验证。
