Cheang Iokfai, Zhu Xu, Yue Xin, Tang Yuan, Gao Yujie, Lu Xinyi, Shi Shi, Liao Shengen, Yao Wenming, Zhou Yanli, Zhang Haifeng, Zhu Yinsu, Xu Yi, Li Xinli
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China.
Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China.
iScience. 2023 Apr 27;26(5):106755. doi: 10.1016/j.isci.2023.106755. eCollection 2023 May 19.
The purpose of this study is to explore the prognostic values of ventricle epicardial fat volume (EFV) calculated by cardiac magnetic resonance in patients with chronic heart failure (CHF). A total of 516 patients with CHF (left ventricular ejection fraction ≤ 50%) were recruited, and 136 (26.4%) of whom experienced major adverse cardiovascular events (MACE) within median follow-up of 24 months. The target marker-EFV was found to be associated with MACE in both univariate and multivariable analysis adjusted for various clinical variables (p < 0.01), regardless as a continuous variable and categorized by X-tile program. EFV also showed promising predictive ability, with an area under the curve of 0.612, 0.618, and 0.687 for the prediction of 1-year, 2-year, and 3-year MACE, respectively. In conclusion, EFV could be a useful prognostic marker for CHF patients, helping to identify individuals at greater risk of MACE.
本研究的目的是探讨通过心脏磁共振计算得出的心室心外膜脂肪体积（EFV）在慢性心力衰竭（CHF）患者中的预后价值。共招募了516例CHF患者（左心室射血分数≤50%），其中136例（26.4%）在24个月的中位随访期内发生了主要不良心血管事件（MACE）。在对各种临床变量进行调整的单变量和多变量分析中，发现目标标志物EFV与MACE相关（p<0.01），无论是作为连续变量还是通过X-tile程序分类。EFV还显示出有前景的预测能力，预测1年、2年和3年MACE的曲线下面积分别为0.612、0.618和0.687。总之，EFV可能是CHF患者有用的预后标志物，有助于识别发生MACE风险更高的个体。
