State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, PR China.
Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, PR China.
J Chromatogr A. 2023 Jul 19;1701:464062. doi: 10.1016/j.chroma.2023.464062. Epub 2023 May 11.
Herein, four amine-modified amphiphilic resins were synthesized and utilized as solid-phase extraction (SPE) materials to enrich pharmaceuticals and personal care products (PPCPs) from environmental water. The obtained materials (Strong anion-exchange amphiphilic materials, SAAMs; Weak anion-exchange amphiphilic materials, WAAMs) possessed large specific surface area (473-626 m/g), high ion exchange capacity (0.89-1.97 mmol/g), and small contact angle (74.41-79.74°), indicating good hydrophilicity. The main factors affecting the efficiency of the extraction process were studied, including column volume, column flow rate, sample salinity and sample pH. Notably, the trend observed in absolute recovery was significantly correlated with the Zeta potential of the employed adsorbents. Furthermore, based on the obtained materials, a method of SPE coupled with ultra-performance liquid chromatography and tandem mass spectrometry (SPE/LC-MS/MS) was developed, and then utilized to determine PPCPs in the samples collected from the Yangtze River Delta. The Method detection limit (MDL) and Method quantification limit (MQL) ranged from 0.05 to 0.60 ng/L and 0.17 to 2.00 ng/L, respectively, with a relative standard deviation (RSD) below 6.3%, demonstrating good accuracy and sensitivity. As evidenced by comparison with previous literature, the developed method exhibited satisfactory performance, showing great potential for further commercial application in the extraction of trace PPCPs from environmental water samples.
本文合成了四种胺基修饰的两亲性树脂，并将其用作固相萃取（SPE）材料，从环境水样中富集药品和个人护理产品（PPCPs）。所得材料（强阴离子交换型两亲性材料，SAAMs；弱阴离子交换型两亲性材料，WAAMs）具有较大的比表面积（473-626 m/g）、高离子交换容量（0.89-1.97 mmol/g）和小接触角（74.41-79.74°），表明具有良好的亲水性。研究了影响萃取过程效率的主要因素，包括柱体积、柱流速、样品盐度和样品 pH 值。值得注意的是，观察到的绝对回收率趋势与所使用的吸附剂的 Zeta 电位显著相关。此外，基于所获得的材料，开发了一种固相萃取（SPE）与超高效液相色谱和串联质谱（SPE/LC-MS/MS）联用的方法，并用于测定从长江三角洲采集的样品中的 PPCPs。方法检测限（MDL）和方法定量限（MQL）分别在 0.05-0.60ng/L 和 0.17-2.00ng/L 范围内，相对标准偏差（RSD）低于 6.3%，具有良好的准确性和灵敏度。通过与先前的文献进行比较，所开发的方法表现出良好的性能，在从环境水样中提取痕量 PPCPs 方面具有很大的商业应用潜力。
