Department of Chemistry, Brown University, RI, 02912, USA.
Department of Chemistry, Brown University, RI, 02912, USA.
Curr Opin Chem Biol. 2023 Aug;75:102325. doi: 10.1016/j.cbpa.2023.102325. Epub 2023 May 20.
Polysulfides (RSSSR, n ≥ 1) are a class of sulfane sulfur compounds that have gained significant recent attention due to their connections to hydrogen sulfide (HS) and hydropersulfides (RSSH), which are known to play important roles in redox signaling. While the potential regulatory functions of polysulfides in biological systems have been recognized for a long time, understanding their interactions with HS/RSSH have only recently begun. In this Mini Review, some of the most recent discoveries of polysulfides within biological contexts are summarized and these include their biological formation pathways, detection methods for animal and plant samples, properties, and unique functions. These studies have set up a solid foundation for understanding polysulfide biology, and more mechanistic details are expected to be discovered in the coming years.
多硫化物（RSSSR，n≥1）是一类硫烷硫化合物，由于它们与硫化氢（HS）和过硫化物（RSSH）的联系，近年来受到了广泛关注，已知 HS 和 RSSH 在氧化还原信号中发挥着重要作用。虽然多硫化物在生物系统中的潜在调节功能早已被人们所认识，但它们与 HS/RSSH 的相互作用直到最近才开始被研究。在这篇综述中，总结了一些最近在生物环境中发现的多硫化物的发现，包括它们的生物形成途径、动植物样本的检测方法、性质和独特的功能。这些研究为理解多硫化物生物学奠定了坚实的基础，预计在未来几年将发现更多的机制细节。
