联合检测血清 CXCL8、CXCL9 和 CXCL13 对肝癌微血管侵犯的预测价值。

Combined serum CXCL8, CXCL9 and CXCL13 tests for the prediction of microvascular invasion in hepatocellular carcinoma.

机构信息

Department of General Surgery, Fifth People's Hospital, No. 1215 Guangrui Road, Liangxi District, Wuxi, Jiangsu, 214007, China.

Department of Hepatobiliary Surgery, the 904th Hospital of Joint Logistic Support Force of PLA, No. 101 Xingyuan North Road, Wuxi, Jiangsu, 214044, China.

出版信息

Biomark Med. 2023 Mar;17(5):265-272. doi: 10.2217/bmm-2023-0064. Epub 2023 May 23.

DOI:10.2217/bmm-2023-0064

PMID:37218545

Abstract

This work is to explore the predictive and diagnostic value of chemokine C-X-C motif ligand 8 (CXCL8), CXCL9 and CXCL13 combined detections for microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients. A total of 82 HCC patients with MVI were recruited as the MVI group and 154 patients with non MVI were recruited as the non MVI group. In HCC patients with MVI, CXCL8, CXCL9, CXCL13 levels were significantly elevated. Child-Pugh scores and serum α-fetoprotein level had positive correlation with CXCL8, CXCL9 and CXCL13 levels. The serum levels of CXCL8, 9 and 13 were effective in predicting MVI in HCC patients. CXCL8, CXCL9 and CXCL13 levels in HCC patients are valuable parameters in the prediction of MVI.

摘要

本研究旨在探讨趋化因子 C-X-C 基序配体 8（CXCL8）、CXCL9 和 CXCL13 联合检测对肝细胞癌（HCC）患者微血管侵犯（MVI）的预测和诊断价值。共招募 82 例 MVI 肝癌患者为 MVI 组，招募 154 例非 MVI 肝癌患者为非 MVI 组。在 MVI 肝癌患者中，CXCL8、CXCL9 和 CXCL13 水平显著升高。Child-Pugh 评分和血清甲胎蛋白水平与 CXCL8、CXCL9 和 CXCL13 水平呈正相关。血清 CXCL8、9 和 13 水平可有效预测 HCC 患者的 MVI。HCC 患者 CXCL8、CXCL9 和 CXCL13 水平是预测 MVI 的有价值参数。