Department of Pathology, Hind Institute of Medical Sciences, Safedabad, Barabanki, Uttar Pradesh, India.
Department of Microbiology, Hind Institute of Medical Sciences, Safedabad, Barabanki, Uttar Pradesh, India.
Diagn Cytopathol. 2023 Aug;51(8):E239-E241. doi: 10.1002/dc.25169. Epub 2023 May 23.
Trichophyton is a dermatophytic fungi causing superficial skin infections which affects outermost layer of the epidermis, stratum corneum, and mainly involves feet, groin, scalp, and nails. Invasion into the dermis occurs mainly in immunocompromised patients. A 75-year-old hypertensive female presented with a nodular swelling on the dorsum of right foot for 1 month. The swelling was 1.0 × 1.0 cm and gradually progressive in nature. FNAC revealed many thin filamentous branching and fungal hyphae along with foreign body granulomas and suppurative acute inflammation. The swelling was excised and sent for histopathological examination which confirmed the above findings. Periodic Acid Schiff stain showed fungal hyphae in both cytology smear as well as histopathology section. On fungal culture, microconidia with septate hyphae suggestive of Trichophyton rubrum was seen. Trichophytons mainly affect immunocompromised and diabetic patients, however, may present as nodular lesions without any history of superficial dermatophytosis as seen in the present case. The characteristic cytological picture helped to clinch the diagnosis in this case and facilitated further management.
须癣毛癣菌是一种引起皮肤浅表真菌感染的真菌，主要侵犯表皮的最外层，即角质层，常累及足部、腹股沟、头皮和指甲。真皮侵犯主要发生于免疫功能低下的患者。一位 75 岁的女性高血压患者，1 个月前出现右足背部结节性肿胀。该肿胀为 1.0×1.0cm，呈进行性增大。细针穿刺抽吸细胞学检查显示有许多薄的丝状分支和真菌菌丝，伴有异物肉芽肿和化脓性急性炎症。切除肿胀组织送检组织病理学检查，证实了上述发现。过碘酸雪夫染色显示细胞学涂片和组织病理学切片中均有真菌菌丝。微菌核和分隔的菌丝提示为红色毛癣菌。须癣毛癣菌主要影响免疫功能低下和糖尿病患者，但也可能表现为结节性病变，而无浅表皮肤癣病史，如本例所见。特征性细胞学图像有助于确诊，并为进一步治疗提供便利。
