Chatziandreou Efstathia, Eustathiou Andreas, Augoulea Areti, Armeni Eleni, Mili Nikoletta, Boutas Ioannis, Tsoltos Nikolaos, Kapetanaki Antigoni, Kalantaridou Sofia
2nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, GR-11528 Athens, Greece.
3rd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, GR-11528 Athens, Greece.
Geriatrics (Basel). 2023 May 19;8(3):57. doi: 10.3390/geriatrics8030057.
This study aimed to assess an eligible cut-off value of anti-Müllerian hormone (AMH) to detect ovarian senescence in a group of premenopausal Greek women to evaluate the possible link between AMH-values and the severity of climacteric symptoms during a follow-up of 24 months. This study included 180 women (group A, 96 women of late reproductive stage/early perimenopause; group B, 84 women in late perimenopause). We measured AMH blood levels and assessed climacteric symptoms using the Greene scale. Log-AMH is inversely associated with postmenopausal status. The AMH cut-off of 0.012 ng/mL predicts the postmenopausal status with a sensitivity of 24.2% and specificity of 30.5%. The postmenopausal stage associated with age (OR = 1.320, 95%CI: 1.084-1.320) and AMH (values ≥ vs. <0.012 ng/mL, OR = 0.225, 95%CI: 0.098-0.529, -value < 0.001). Moreover, the severity of vasomotor symptoms (VMS) was only associated inversely with AMH (b-coefficient = -0.272, -value = 0.027). In conclusion, AMH levels measured in the late premenopausal period are inversely associated with the time to ovarian senescence. In contrast, AMH levels measured in the perimenopausal period are inversely associated only with the severity of VMS. Therefore, a cut-off of 0.012 ng/mL predicts menopause with low sensitivity and specificity, making it challenging to use in a clinical setting.
本研究旨在评估抗苗勒管激素（AMH）的合格临界值，以检测一组希腊绝经前女性的卵巢衰老情况，并在24个月的随访期间评估AMH值与更年期症状严重程度之间的可能联系。本研究纳入了180名女性（A组，96名处于生殖后期/围绝经期早期的女性；B组，84名处于围绝经期晚期的女性）。我们测量了AMH血液水平，并使用格林量表评估了更年期症状。Log-AMH与绝经后状态呈负相关。AMH临界值为0.012 ng/mL时，预测绝经后状态的敏感性为24.2%，特异性为30.5%。绝经后阶段与年龄相关（OR = 1.320，95%CI：1.084 - 1.320）以及与AMH相关（值≥与<0.012 ng/mL，OR = 0.225，95%CI：0.098 - 0.529，P值<0.001）。此外，血管舒缩症状（VMS）的严重程度仅与AMH呈负相关（b系数 = -0.272，P值 = 0.027）。总之，绝经前后期测量的AMH水平与卵巢衰老时间呈负相关。相比之下，围绝经期测量的AMH水平仅与VMS的严重程度呈负相关。因此，0.012 ng/mL的临界值预测绝经的敏感性和特异性较低，在临床环境中使用具有挑战性。
