Widdershoven J, Motohara K, Endo F, Matsuda I, Monnens L
Helv Paediatr Acta. 1986 May;41(1-2):25-9.
PIVKA-II levels were studied by a highly sensitive immunological method in two groups of infants, breast-fed and bottle-fed, at the age of 4 days, 1 month, 2 months, and 3 months. PIVKA-II could be demonstrated in 9 infants after the age of 1 month when they were breast-fed. In none of the bottle-fed infants PIVKA-II was present during the same period. This significant difference can probably be explained by the lower vitamin K1 content of human milk compared to commercial formulas. The frequently occurring biochemical deficiency of vitamin K indicates the need of prophylactic administration of vitamin K to all newborns.
采用高灵敏度免疫方法，对两组分别为母乳喂养和人工喂养的婴儿在4日龄、1月龄、2月龄和3月龄时的异常凝血酶原-II（PIVKA-II）水平进行了研究。母乳喂养的婴儿在1月龄后，有9例可检测到PIVKA-II。而在同一时期，人工喂养的婴儿均未检测到PIVKA-II。这一显著差异可能是由于母乳中维生素K1的含量低于商业配方奶粉。维生素K频繁出现的生化缺乏表明，有必要对所有新生儿进行维生素K的预防性给药。
