Institut Imagine, INSERM UMR1163, Paris Cité University, France.
Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA.
FEBS Open Bio. 2023 Sep;13(9):1558-1579. doi: 10.1002/2211-5463.13651. Epub 2023 Jun 4.
Glycolipid balance is key to normal body function, and its alteration can lead to a variety of diseases involving multiple organs and tissues. Glycolipid disturbances are also involved in Parkinson's disease (PD) pathogenesis and aging. Increasing evidence suggests that glycolipids affect cellular functions beyond the brain, including the peripheral immune system, intestinal barrier, and immunity. Hence, the interplay between aging, genetic predisposition, and environmental exposures could initiate systemic and local glycolipid changes that lead to inflammatory reactions and neuronal dysfunction. In this review, we discuss recent advances in the link between glycolipid metabolism and immune function and how these metabolic changes can exacerbate immunological contributions to neurodegenerative diseases, with a focus on PD. Further understanding of the cellular and molecular mechanisms that control glycolipid pathways and their impact on both peripheral tissues and the brain will help unravel how glycolipids shape immune and nervous system communication and the development of novel drugs to prevent PD and promote healthy aging.
糖脂平衡是正常身体功能的关键，其改变可能导致涉及多个器官和组织的各种疾病。糖脂紊乱也涉及帕金森病 (PD) 的发病机制和衰老。越来越多的证据表明，糖脂会影响大脑以外的细胞功能，包括外周免疫系统、肠道屏障和免疫。因此，衰老、遗传易感性和环境暴露之间的相互作用可能会引发全身性和局部糖脂变化，导致炎症反应和神经元功能障碍。在这篇综述中，我们讨论了糖脂代谢与免疫功能之间的最新联系，以及这些代谢变化如何加剧免疫因素对神经退行性疾病的贡献，重点是 PD。进一步了解控制糖脂途径的细胞和分子机制及其对周围组织和大脑的影响，将有助于揭示糖脂如何塑造免疫和神经系统的交流，以及开发预防 PD 和促进健康衰老的新型药物。
