Faculty of Science, The University of New South Wales, High Street, Sydney, New South Wales 2052, Australia.
Inner Mongolia Autonomous Region Key Laboratory of Big Data Research and Application for Agriculture and Animal Husbandry, Zhaowuda Road No. 306, Hohhot 010018, China.
Database (Oxford). 2023 May 23;2023. doi: 10.1093/database/baad036.
In a broad sense, lactic acid bacteria (LAB) is a general term for Gram-positive bacteria that can produce lactic acid by utilizing fermentable carbohydrates. It is widely used in essential fields such as industry, agriculture, animal husbandry and medicine. At the same time, LAB are closely related to human health. They can regulate human intestinal flora and improve gastrointestinal function and body immunity. Cancer, a disease in which some cells grow out of control and spread to other body parts, is one of the leading causes of human death worldwide. In recent years, the potential of LAB in cancer treatment has attracted attention. Mining knowledge from the scientific literature significantly accelerates its application in cancer treatment. Using 7794 literature studies of LAB cancer as source data, we have processed 16 543 biomedical concepts and 23 091 associations by using automatic text mining tools combined with manual curation of domain experts. An ontology containing 31 434 pieces of structured data is constructed. Finally, based on ontology, a knowledge graph (KG) database, which is called Beyond 'Lactic acid bacteria to Cancer Knowledge graph Database' (BLAB2CancerKD), is constructed by using KG and web technology. BLAB2CancerKD presents all the relevant knowledge intuitively and clearly in various data presentation forms, and the interactive system function also makes it more efficient. BLAB2CancerKD will be continuously updated to advance the research and application of LAB in cancer therapy. Researchers can visit BLAB2CancerKD at. Database URL http://110.40.139.2:18095/.
广义而言，乳酸菌（LAB）是指能够利用可发酵碳水化合物产生乳酸的革兰氏阳性细菌的统称。它广泛应用于工业、农业、畜牧业和医学等重要领域。同时，LAB 与人类健康密切相关。它们可以调节人体肠道菌群，改善胃肠道功能和身体免疫力。癌症是一种某些细胞失控生长并扩散到身体其他部位的疾病，是全球导致人类死亡的主要原因之一。近年来，LAB 在癌症治疗中的潜力引起了人们的关注。从科学文献中挖掘知识可以显著加速其在癌症治疗中的应用。我们使用自动文本挖掘工具结合领域专家的手动策展，处理了 7794 篇关于 LAB 癌症的文献研究，从中提取了 16543 个生物医学概念和 23091 个关联。构建了一个包含 31434 个结构化数据的本体。最后，基于本体，使用知识图（KG）和网络技术构建了一个知识图（KG）数据库，称为超越“乳酸菌到癌症知识图数据库”（BLAB2CancerKD）。BLAB2CancerKD 以各种数据呈现形式直观、清晰地呈现了所有相关知识，交互式系统功能也使其更加高效。BLAB2CancerKD 将不断更新，以推进 LAB 在癌症治疗中的研究和应用。研究人员可以访问 BLAB2CancerKD，网址为。数据库 URL：http://110.40.139.2:18095/。
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