School of Clinical Medicine, Tsinghua University and Department of Orthopedics, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University and National Clinical Research Center for Cardiovascular Diseases, Beijing, China.
Arthritis Care Res (Hoboken). 2023 Dec;75(12):2489-2500. doi: 10.1002/acr.25158. Epub 2023 Jul 13.
OBJECTIVE: To report the global, regional, and national estimates of knee osteoarthritis (OA) burden and associated risk factors (high body mass index [BMI]) by age, sex, and sociodemographic index (SDI) for 204 countries from 1990 to 2019. METHODS: We analyzed the prevalence, incidence, years lived with disability (YLDs), and age-standardized rates of knee OA using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019. Estimates of the knee OA burden were derived from data modeled using a Bayesian meta-regression analytical tool (DisMod-MR 2.1). RESULTS: The global prevalence of knee OA in 2019 was ~364.6 million (95% uncertainty interval [95% UI] 315.3 to 417.4). The age-standardized prevalence in 2019 was 4,376.0 per 100,000 (95% UI 3,793.0 to 5,004.9), an increase of 7.5% between 1990 and 2019. There were ~29.5 million incident cases of knee OA in 2019 (95% UI 25.6 to 33.7), with an age-standardized incidence of 350.3 per 100,000 (95% UI 303.4 to 398.9). The global age-standardized YLD resulting from knee OA was 138.2 (95% UI 68.5 to 281.3) per 100,000 population in 2019, an increase of 7.8% (95% UI 7.1 to 8.4) from 1990. Globally in 2019, 22.4% (95% UI 12.1 to 34.2) of YLD resulting from knee OA was attributable to high BMI, an increase of 40.5% since 1990. CONCLUSION: The prevalence, incidence, YLDs, and age-standardized rates of knee OA increased substantially in most countries and regions from 1990 to 2019. Continuous monitoring of this burden is important for establishing appropriate public prevention policies and raising public awareness, especially in high- and high-middle SDI regions.
目的：报告全球、区域和国家 1990 年至 2019 年膝关节骨关节炎（OA）负担和相关危险因素（高体重指数[BMI]）的估计值，按年龄、性别和社会人口指数（SDI）进行分层。
方法：我们利用全球疾病、伤害和危险因素研究 2019 年的数据，分析了膝关节 OA 的患病率、发病率、残疾生存年数（YLDs）和年龄标准化率。膝关节 OA 负担的估计值来自使用贝叶斯荟萃回归分析工具（DisMod-MR 2.1）对数据进行建模得出。
结果：2019 年全球膝关节 OA 的患病率约为 3.646 亿（95%置信区间[95%UI]为 3.153 亿至 4.174 亿）。2019 年年龄标准化患病率为 4376.0/100000（95%UI 为 3793.0 至 5004.9），1990 年至 2019 年间增长了 7.5%。2019 年膝关节 OA 的新发病例约为 2950 万（95%UI 为 2560 万至 3370 万），年龄标准化发病率为 350.3/100000（95%UI 为 303.4 至 398.9）。2019 年全球因膝关节 OA 导致的年龄标准化 YLD 为 138.2（95%UI 为 68.5 至 281.3）/100000 人口，比 1990 年增长了 7.8%（95%UI 为 7.1%至 8.4%）。2019 年，全球膝关节 OA 导致的 YLD 中，22.4%（95%UI 为 12.1%至 34.2%）归因于高 BMI，自 1990 年以来增长了 40.5%。
结论：1990 年至 2019 年，大多数国家和地区膝关节 OA 的患病率、发病率、YLDs 和年龄标准化率都有大幅上升。持续监测这一负担对制定适当的公共预防政策和提高公众认识非常重要，特别是在高和高中等 SDI 地区。
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