Ouyang Yi, Dai Miaomiao
Department of Joint Surgery, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), No.1 Jiazi Road, Lunjiao, Shunde District, Foshan City, Guangdong Province, China.
Department of Ophthalmology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), No.1 Jiazi Road, Lunjiao, Shunde District, Foshan City, Guangdong Province, China.
J Orthop Surg Res. 2025 Aug 13;20(1):766. doi: 10.1186/s13018-025-06140-0.
BACKGROUND: Osteoarthritis is a major contributor to the global disease burden, with the knee being the most commonly affected site. Comprehensive research on knee osteoarthritis (KOA) at a global scale carries significant implications for public health. METHODS: The estimates and 95% uncertainty intervals (UIs) for prevalence, incidence and disability-adjusted life years (DALYs) of KOA were extracted from Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021. We described KOA epidemiology at global, regional, and national levels, analyzed 1990-2021 trends in KOA burden from overall, local, and multi-dimension scopes, decomposed KOA burden according to population size, age structure, and epidemiologic changes, quantified cross-country inequalities in KOA burden using standard health equity methods recommended by World Health Organization, and predicted changes of KOA burden to 2045. RESULTS: GBD 2021 estimated 374,738,744 (95% UI: 321,858,982-428,353,220) prevalent cases, 30,845,891 (95% UI: 26,534,151-35,188,905) incident cases and 12,019,070 (95% UI: 67.08-266.87) DALYs cases of KOA worldwide in 2021. An overall increase in prevalence rates, incidence rates and DALYs rates were observed from 1990 to 2021. And the prevalence number, incidence number and rates were consistently higher in females compared to males. Decomposition analysis revealed that aging, population growth, and epidemiological changes contributed 15.6%, 74.72%, and 9.69% to the global increase in age-standardized prevalence rate, respectively. A decrease in Socio-Demographic Index (SDI)-related inequalities was detected. Notably, the case number of these metrics were predicted to keeping increasing, with predicted values of 658,088,384.48 (322,110,040.98-994,066,727.98), 47,256,502.97 (23,440,017.7-71,072,988.23) and 20,517,479.78 (10,056,930.68-30,978,028.88), respectively. CONCLUSIONS: The global burden of KOA has shown a consistent upward trend from 1990 to 2021, primarily driven by population growth and aging demographics. Countries with high SDI faced a disproportionately high burden of KOA, although inequalities related to SDI among nations have decreased over time. This study underscores significant challenges in managing KOA, including the increasing number of cases and ongoing disparities worldwide.
背景：骨关节炎是全球疾病负担的主要成因，膝关节是最常受累的部位。在全球范围内对膝关节骨关节炎（KOA）进行全面研究对公共卫生具有重大意义。 方法：从《2021年全球疾病、伤害和风险因素研究》（GBD 2021）中提取KOA患病率、发病率和伤残调整生命年（DALYs）的估计值及95%不确定性区间（UIs）。我们描述了全球、区域和国家层面的KOA流行病学情况，从总体、局部和多维度范围分析了1990 - 2021年KOA负担的趋势，根据人口规模、年龄结构和流行病学变化对KOA负担进行分解，使用世界卫生组织推荐的标准健康公平方法量化各国KOA负担的不平等情况，并预测了到2045年KOA负担的变化。 结果：GBD 2021估计2021年全球KOA患病例数为374,738,744例（95% UI：321,858,982 - 428,353,220），新发病例数为30,845,891例（95% UI：26,534,151 - 35,188,905），DALYs病例数为12,019,070例（95% UI：67.08 - 266.87）。1990年至2021年期间，患病率、发病率和DALYs率总体呈上升趋势。女性的患病率、发病率及相应比率始终高于男性。分解分析表明，老龄化、人口增长和流行病学变化对全球年龄标准化患病率增长的贡献率分别为15.6%、74.72%和9.69%。社会人口指数（SDI）相关的不平等有所减少。值得注意的是，预计这些指标的病例数将持续增加，预测值分别为658,088,384.48例（322,110,040.98 - 994,066,727.98）、47,256,502.97例（23,440,017.7 - 71,072,988.23）和20,517,479.78例（10,056,930.68 - 30,978,028.88）。 结论：1990年至2021年期间，全球KOA负担呈持续上升趋势，主要由人口增长和人口老龄化驱动。高SDI国家面临的KOA负担过高，尽管各国之间与SDI相关的不平等随时间有所减少。本研究强调了KOA管理面临的重大挑战，包括全球病例数不断增加以及持续存在的差异。
BMC Musculoskelet Disord. 2025-7-1
Front Med (Lausanne). 2024-5-16
Zotero 插件