关于钾离子对琥珀酸脱氢酶活性的作用

On the role of K+ on succinic dehydrogenase activity.

作者信息

Chávez E, Bravo C, Jay D

出版信息

J Bioenerg Biomembr. 1986 Apr;18(2):93-9. doi: 10.1007/BF00743478.

Abstract

The effect of potassium ions on succinic dehydrogenase activity of mitochondria was studied. The results showed that in these organelles K+ induces inhibition of the respiratory control; moreover, in submitochondrial particles potassium inhibits the rate of oxidation of succinate. The results showed also that K+ does not changes the Km for succinate but diminishes the Vmax. In addition, the data provide evidence that mitochondria oxidizing glutamate-malate in a sucrose medium show a higher activity of succinate dehydrogenase than mitochondria incubated in KCl.

摘要

研究了钾离子对线粒体琥珀酸脱氢酶活性的影响。结果表明，在这些细胞器中，K⁺ 会抑制呼吸控制；此外，在亚线粒体颗粒中，钾会抑制琥珀酸的氧化速率。结果还表明，K⁺ 不会改变琥珀酸的 Km，但会降低 Vmax。此外，数据表明，在蔗糖培养基中氧化谷氨酸 - 苹果酸的线粒体比在 KCl 中孵育的线粒体具有更高的琥珀酸脱氢酶活性。