A型肉毒毒素注射治疗甲状腺相关眼病引起的上睑退缩。

Botulinum Toxin Type A Injection for Correction of Upper Eyelid Retraction in Thyroid-Associated Ophthalmopathy.

机构信息

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine.

Department of Plastic Surgery, People's Hospital of Zhaoyuan City.

出版信息

J Craniofac Surg. 2023;34(5):e485-e488. doi: 10.1097/SCS.0000000000009347. Epub 2023 May 24.

DOI:10.1097/SCS.0000000000009347

PMID:37221639

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10292564/

Abstract

Upper lid retraction (ULR) is the most common and earliest symptom in thyroid-associated ophthalmopathy (TAO) patients. Surgical correction is effective for ULR in stable diseases. However, non-invasive treatment is also required for the TAO patient in active phase. Here, we reported a complex case with TAO and unilateral ULR simultaneously. The patient had a history of progressive ptosis in the left eyelid and underwent anterior levator aponeurotic-Muller muscle resection to correct the ptosis. However, the patient gradually developed bilateral proptosis and ULR, mainly in the left eyelid. The patient was finally diagnosed with TAO with left ULR. Then, the patient was treated with botulinum toxin type A (BTX-A) injection in the left eyelid. The effect of BTX-A treatment started 7 days after injection, peaked at one month, and lasted for approximately 3 months. This study highlighted the therapeutic effect of BTX-A injection for the treatment of ULR-related TAO.

摘要

上睑退缩（ULR）是甲状腺相关眼病（TAO）患者最常见和最早的症状。对于稳定期的 ULR，手术矫正效果良好。然而，对于活动期的 TAO 患者，还需要非侵入性治疗。在这里，我们报告了一例同时患有 TAO 和单侧 ULR 的复杂病例。该患者有左眼逐渐出现上睑下垂的病史，并接受了提上睑肌前膜-Müller 肌切除术以矫正上睑下垂。然而，患者逐渐出现双侧眼球突出和 ULR，主要发生在左眼。最终，患者被诊断为 TAO 伴左侧 ULR。随后，患者接受了左侧眼睑肉毒杆菌毒素 A（BTX-A）注射治疗。BTX-A 治疗的效果在注射后 7 天开始显现，一个月时达到峰值，持续约 3 个月。本研究强调了 BTX-A 注射治疗与 TAO 相关 ULR 的疗效。