Costa Patrícia Grativol, Saraiva Fábio Petersen, Matayoshi Suzana
Departamento de Otorrinolaringologia e Oftalmologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, SP.
Arq Bras Endocrinol Metabol. 2006 Oct;50(5):920-5. doi: 10.1590/s0004-27302006000500014.
Botulinum toxin is an alternative treatment for retraction of ocular thyroid related dysfunction. The aim of this study was to evaluate the effects of this medication on upper lid position, levator palpebrae superioris muscle function and corneal exposure.
Seven patients were enrolled into the study. The palpebral fissure images were acquired by a digital camera and transferred to a computer video edition program in order to be processed and analyzed. The levator palpebrae superioris muscle function and lacrimal film tests were also studied.
The distance between upper eyelid superior margin and light reflection on the center of the cornea had a significantly reduction in its measurements after toxin injection. The muscle function was diminished and there were improvement in corneal exposure after treatment.
Botulinum toxin injection could be an alternative treatment for upper eyelid retraction; it may relieve symptoms and improve eye appearance.
肉毒杆菌毒素是治疗眼部甲状腺相关功能障碍回缩的一种替代疗法。本研究的目的是评估这种药物对上睑位置、提上睑肌功能和角膜暴露的影响。
七名患者纳入本研究。通过数码相机获取睑裂图像，并将其传输到计算机视频编辑程序中进行处理和分析。还研究了提上睑肌功能和泪膜测试。
注射毒素后，上睑上缘与角膜中心光反射之间的距离测量值显著减小。治疗后肌肉功能减弱，角膜暴露情况有所改善。
肉毒杆菌毒素注射可能是上睑回缩的一种替代治疗方法；它可能缓解症状并改善眼部外观。
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