European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), Heidelberg, Germany.
Physiology (Bethesda). 2023 Jul 1;38(4):0. doi: 10.1152/physiol.00001.2023.
Proliferating cancer cells secrete a multitude of factors impacting metabolism, interorgan communication, and tumor progression. The distribution of tumor-derived factors to distant organs occurs via the circulation, which provides an extensive reactive surface lined by endothelial cells. Primary tumor-derived proteins impact cancer progression by modulating endothelial cell activation at the (pre-)metastatic niche, which affects tumor cell dissemination as well as the outgrowth of seeded metastatic cells into overt tumors. In addition, new insight indicates that endothelial cell signaling contributes to metabolic symptoms of cancer, including cancer-associated cachexia, opening a new field of vascular metabolism research. This review addresses how tumor-derived factors systemically affect endothelial cell signaling and activation and impact distant organs as well as tumor progression.
增殖的癌细胞会分泌大量影响代谢、器官间通讯和肿瘤进展的因子。肿瘤衍生因子通过循环系统分布到远处器官，该循环系统提供了一个广泛的反应表面，由内皮细胞排列。原发肿瘤衍生的蛋白质通过调节（前）转移部位的内皮细胞激活来影响癌症进展，这会影响肿瘤细胞的扩散以及播种转移细胞的生长为明显的肿瘤。此外，新的研究表明，内皮细胞信号转导有助于癌症的代谢症状，包括癌症相关的恶病质，开辟了血管代谢研究的新领域。这篇综述讨论了肿瘤衍生因子如何系统地影响内皮细胞信号转导和激活，并影响远处器官和肿瘤进展。
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