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休克指数、改良休克指数和格拉斯哥昏迷评分乘以休克指数在成年创伤患者死亡率中的鉴别能力:一项 PATOS 回顾性队列研究。

Discriminant ability of the shock index, modified shock index, and reverse shock index multiplied by the Glasgow coma scale on mortality in adult trauma patients: a PATOS retrospective cohort study.

机构信息

Department of Emergency Medicine, Mackay Memorial Hospital.

Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation.

出版信息

Int J Surg. 2023 May 1;109(5):1231-1238. doi: 10.1097/JS9.0000000000000287.

DOI:10.1097/JS9.0000000000000287
PMID:37222717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10389576/
Abstract

BACKGROUND

The shock index (SI) predicts short-term mortality in trauma patients. Other shock indices have been developed to improve discriminant accuracy. The authors examined the discriminant ability of the SI, modified SI (MSI), and reverse SI multiplied by the Glasgow Coma Scale (rSIG) on short-term mortality and functional outcomes.

METHODS

The authors evaluated a cohort of adult trauma patients transported to emergency departments. The first vital signs were used to calculate the SI, MSI, and rSIG. The areas under the receiver operating characteristic curves and test results were used to compare the discriminant performance of the indices on short-term mortality and poor functional outcomes. A subgroup analysis of geriatric patients with traumatic brain injury, penetrating injury, and nonpenetrating injury was performed.

RESULTS

A total of 105 641 patients (49±20 years, 62% male) met the inclusion criteria. The rSIG had the highest areas under the receiver operating characteristic curve for short-term mortality (0.800, CI: 0.791-0.809) and poor functional outcome (0.596, CI: 0.590-0.602). The cutoff for rSIG was 18 for short-term mortality and poor functional outcomes with sensitivities of 0.668 and 0.371 and specificities of 0.805 and 0.813, respectively. The positive predictive values were 9.57% and 22.31%, and the negative predictive values were 98.74% and 89.97%. rSIG also had better discriminant ability in geriatrics, traumatic brain injury, and nonpenetrating injury.

CONCLUSION

The rSIG with a cutoff of 18 was accurate for short-term mortality in Asian adult trauma patients. Moreover, rSIG discriminates poor functional outcomes better than the commonly used SI and MSI.

摘要

背景

休克指数(SI)可预测创伤患者的短期死亡率。其他休克指数也已被开发出来以提高判别准确性。作者研究了 SI、改良 SI(MSI)和格拉斯哥昏迷量表(GCS)乘以 SI 的倒数(rSIG)在短期死亡率和功能结局方面的判别能力。

方法

作者评估了一组送往急诊科的成年创伤患者队列。使用首次生命体征计算 SI、MSI 和 rSIG。使用受试者工作特征曲线下面积和检验结果来比较这些指数在短期死亡率和不良功能结局方面的判别性能。对患有创伤性脑损伤、穿透性损伤和非穿透性损伤的老年患者进行了亚组分析。

结果

共有 105641 名患者(49±20 岁,62%为男性)符合纳入标准。rSIG 在短期死亡率(0.800,CI:0.791-0.809)和不良功能结局(0.596,CI:0.590-0.602)方面的受试者工作特征曲线下面积最高。rSIG 的截断值为 18,用于短期死亡率和不良功能结局的灵敏度分别为 0.668 和 0.371,特异性分别为 0.805 和 0.813。阳性预测值分别为 9.57%和 22.31%,阴性预测值分别为 98.74%和 89.97%。rSIG 在老年患者、创伤性脑损伤和非穿透性损伤中也具有更好的判别能力。

结论

rSIG 的截断值为 18 时可准确预测亚洲成年创伤患者的短期死亡率。此外,rSIG 在判别不良功能结局方面优于常用的 SI 和 MSI。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ada/10389576/2c4b4b0a4b3c/js9-109-1231-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ada/10389576/db67c3e3328d/js9-109-1231-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ada/10389576/e9a96e62494b/js9-109-1231-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ada/10389576/2c4b4b0a4b3c/js9-109-1231-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ada/10389576/db67c3e3328d/js9-109-1231-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ada/10389576/e9a96e62494b/js9-109-1231-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ada/10389576/2c4b4b0a4b3c/js9-109-1231-g003.jpg

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