Department of Emergency and Critical Care, Center Hospital of the National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku City, Tokyo, 162-8655, Japan.
Biostatistics Section, Department of Data Science, Clinical Science Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku City, Tokyo, 162-8655, Japan.
Crit Care. 2018 Apr 11;22(1):87. doi: 10.1186/s13054-018-2014-0.
The shock index (SI), defined as heart rate (HR) divided by systolic blood pressure (SBP), is reported to be a more sensitive marker of shock than traditional vital signs alone. In previous literature, use of the reverse shock index (rSI), taken as SBP divided by HR, is recommended instead of SI for hospital triage. Among traumatized patients aged > 55 years, SI multiplied by age (SIA) might provide better prediction of early post-injury mortality. Separately, the Glasgow Coma Scale (GCS) score has been shown to be a very strong predictor. When considering these points together, rSI multiplied by GCS score (rSIG) or rSIG divided by age (rSIG/A) could provide even better prediction of in-hospital mortality.
This retrospective, multicenter study used data from 168,517 patients registered in the Japan Trauma Data Bank for the period 2006-2015. We calculated areas under receiver operating characteristic curves (AUROCs) to measure the discriminant ability by comparing those of SI (or rSI), SIA, rSIG, and rSIG/A for in-hospital mortality and for 24-h blood transfusion.
The highest ROC AUC (AUROC), 0.901(0.894-0.908) for in-hospital mortality in younger patients (aged < 55 years), was seen for rSIG. In older patients (aged ≥ 55 years), the AUROC of rSIG/A, 0.845(0.840-0.850), was highest for in-hospital mortality. However, the difference between rSIG and rSIG/A was slight and did not seem to be clinically important. rSIG also had the highest AUROC of 0.745 (0.741-749) for 24-h blood transfusion.
rSIG ((SBP/HR) × GCS score) is easy to calculate without the need for additional information, charts or equipment, and can be a more reliable triage tool for identifying risk levels in trauma patients.
心率(HR)与收缩压(SBP)的比值(SI)被报道为比传统生命体征更敏感的休克标志物。在之前的文献中,建议使用反向休克指数(rSI),即 SBP 与 HR 的比值,而不是 SI 用于医院分诊。对于年龄>55 岁的创伤患者,SI 乘以年龄(SIA)可能会更好地预测受伤后早期死亡率。另外,格拉斯哥昏迷评分(GCS)也被证明是一个非常强的预测指标。当综合考虑这几点时,rSI 乘以 GCS 评分(rSIG)或 rSIG 除以年龄(rSIG/A)可能会更好地预测住院死亡率。
这项回顾性、多中心研究使用了 2006-2015 年期间登记在日本创伤数据库中的 168517 名患者的数据。我们计算了接受者操作特征曲线(AUROCs)下的面积,通过比较 SI(或 rSI)、SIA、rSIG 和 rSIG/A 在住院死亡率和 24 小时输血方面的判别能力来衡量。
在年轻患者(年龄<55 岁)中,rSIG 的 AUROC(AUROC)最高,为 0.901(0.894-0.908),用于住院死亡率。在老年患者(年龄≥55 岁)中,rSIG/A 的 AUROC 最高,为 0.845(0.840-0.850),用于住院死亡率。然而,rSIG 和 rSIG/A 之间的差异很小,似乎没有临床意义。rSIG 对 24 小时输血的 AUROC 也最高,为 0.745(0.741-0.749)。
rSIG(SBP/HR)×GCS 评分)易于计算,无需额外的信息、图表或设备,并且可以成为识别创伤患者风险水平的更可靠分诊工具。