Brescini Lucia, Fioriti Simona, Coccitto Sonia N, Cinthi Marzia, Mingoia Marina, Cirioni Oscar, Giacometti Andrea, Giovanetti Eleonora, Morroni Gianluca, Brenciani Andrea
Infectious Diseases Clinic, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Ancona, Italy.
Unit of Microbiology, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Ancona, Italy.
Microb Drug Resist. 2023 Sep;29(9):388-391. doi: 10.1089/mdr.2022.0330. Epub 2023 May 24.
Although coagulase negative staphylococci are rarely associated with complicated diseases, in some cases they cause life-threatening infections. Here we described a clinical case of a bacteremia due to a methicillin- and linezolid-resistant in a patient previously treated with linezolid. Whole genome sequencing revealed the common mutation G2576T in all rDNA 23S alleles and several acquired resistance genes. Moreover, the isolate was epidemiologically distant from the NRCS-A clade, usually responsible for nosocomial infections in neonatal intensive care units. Our findings further confirm the ability of minor staphylococci to acquire antibiotic resistances and challenge the treatment of these infections.
虽然凝固酶阴性葡萄球菌很少与复杂疾病相关，但在某些情况下它们会引起危及生命的感染。在此，我们描述了一例在先前接受过利奈唑胺治疗的患者中，由耐甲氧西林和耐利奈唑胺的菌株引起的菌血症临床病例。全基因组测序揭示了所有rDNA 23S等位基因中常见的G2576T突变以及几个获得性耐药基因。此外，该分离株在流行病学上与通常导致新生儿重症监护病房医院感染的NRCS-A进化枝相距甚远。我们的研究结果进一步证实了次要葡萄球菌获得抗生素耐药性的能力，并对这些感染的治疗提出了挑战。
