Alidrisi Dhuha A, Alharthi Waad, Alfawaz Tariq
Pediatric Infectious Diseases, Security Forces Hospital Makkah, Makkah, SAU.
Pediatric Infectious Diseases, King Fahad Specialist Hospital, Dammam, SAU.
Cureus. 2023 Apr 22;15(4):e37974. doi: 10.7759/cureus.37974. eCollection 2023 Apr.
developed resistance against most antibiotics; the most known resistant form is methicillin-resistant (MRSA), which can be acquired either from healthcare facilities or the community. The prevalence of hospital-acquired MRSA is higher than community-acquired MRSA (CA-MRSA). CA-MRSA has become an emerging infection and has been increasingly reported recently. Usually, CA-MRSA presents with skin and soft tissue infection but can cause severe invasive infection with significant morbidity. Invasive CA-MRSA needs rapid and aggressive treatment to prevent complications. For MRSA bacteremia that is persistent despite appropriate treatment, the possibility of metastatic invasive infection should be thought of. In this case series, we describe five pediatric cases of different age groups that had different presentations for invasive CA-MRSA infection. This report aims to highlight that physicians should be aware of the growing role of CA-MRSA in pediatrics; they should be meticulous in treating patients with CA-MRSA, and be aware of the complications of this disease and the appropriate empiric and target antibiotics regimen for such infections.
对大多数抗生素产生了耐药性；最著名的耐药形式是耐甲氧西林金黄色葡萄球菌（MRSA），它可以从医疗机构或社区获得。医院获得性MRSA的患病率高于社区获得性MRSA（CA-MRSA）。CA-MRSA已成为一种新出现的感染，最近报告越来越多。通常，CA-MRSA表现为皮肤和软组织感染，但可导致严重的侵袭性感染并伴有显著的发病率。侵袭性CA-MRSA需要迅速积极的治疗以预防并发症。对于尽管进行了适当治疗仍持续存在的MRSA菌血症，应考虑转移性侵袭性感染的可能性。在本病例系列中，我们描述了五例不同年龄组的儿童侵袭性CA-MRSA感染病例，其表现各异。本报告旨在强调医生应意识到CA-MRSA在儿科中日益重要的作用；他们在治疗CA-MRSA患者时应谨慎，并了解该疾病的并发症以及针对此类感染的适当经验性和靶向抗生素治疗方案。
