Katsouli Olga K, Lainis Vasileios G, Kapellos Gerasimos G, Vlachoyiannopoulos Panayiotis G
Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, and Institute for Autoimmune Systemic and Neurologic Diseases, Athens, Greece.
Haematology Department, Athens Medical Center, Athens, Greece.
Mediterr J Rheumatol. 2023 Mar 31;34(1):97-100. doi: 10.31138/mjr.34.1.97. eCollection 2023 Mar.
We report a case of a 52-year-old female with Large Vessel Vasculitis (LVV) after vaccination with Oxford-AstraZeneca COVID-19 vaccine. She was presented with fever, started two weeks after the second dose of vaccine. Laboratory values, revealed elevated inflammatory markers and chronic disease anaemia. All the infectious causes were excluded, and immunology tests were negative. Computed Tomography (CT) demonstrated concentric wall thickening of ascending and descending aorta. Positron Emission Tomography (PET) scan showed increased vascular fluorodeoxyglucose (FDG), compatible with LVV. Within one month of treatment with high dose glucocorticoids and iv cyclophosphamide, laboratory findings normalised, and fever resolved.
我们报告一例52岁女性在接种牛津-阿斯利康新冠疫苗后发生大血管血管炎（LVV）的病例。她在接种第二剂疫苗两周后出现发热。实验室检查结果显示炎症标志物升高以及慢性病贫血。所有感染性病因均被排除，免疫学检查结果为阴性。计算机断层扫描（CT）显示升主动脉和降主动脉壁呈同心性增厚。正电子发射断层扫描（PET）显示血管内氟脱氧葡萄糖（FDG）摄取增加，符合大血管血管炎表现。在接受高剂量糖皮质激素和静脉注射环磷酰胺治疗的一个月内，实验室检查结果恢复正常，发热消退。
