脉冲式促性腺激素释放激素：一种生理模式的临床应用

Reproductive Endocrinology Center, University of Bologna, Bologna, Italy.

F S Rep. 2023 Feb 2;4(2 Suppl):20-26. doi: 10.1016/j.xfre.2023.01.007. eCollection 2023 Jun.

Gonadotropin-releasing hormone (GnRH) is a fundamental driver of human reproduction. A pulsatile pattern of GnRH secretion is essential to achieve pituitary stimulation, gonadotropin secretion, and normal gonadal function. Pulsatile GnRH administration is used to treat anovulation and male hypogonadotropic hypogonadism. Pulsatile GnRH ovulation induction is effective and safe because it allows to avoid ovarian hyperstimulation syndrome and reduce the occurrence of multiple pregnancies. This physiology-inspired therapeutic tool has also permitted to elucidate several pathophysiologic features of human reproductive disorders.

促性腺激素释放激素（GnRH）是人类生殖的基本驱动因素。GnRH分泌的脉冲模式对于实现垂体刺激、促性腺激素分泌和正常性腺功能至关重要。脉冲式GnRH给药用于治疗无排卵和男性低促性腺激素性性腺功能减退。脉冲式GnRH诱导排卵是有效且安全的，因为它可以避免卵巢过度刺激综合征并减少多胎妊娠的发生。这种受生理学启发的治疗工具还有助于阐明人类生殖障碍的几种病理生理特征。