Kokkalis G V, Vinson W E, Akers R M
J Dairy Sci. 1986 May;69(5):1426-31. doi: 10.3168/jds.S0022-0302(86)80551-3.
Preliminary results of bidirectional selection for increased and decreased somatic cell counts in milk of laboratory mice were used to assess the usefulness of the laboratory mouse as a pilot organism for the study of yield and somatic cell count relationships in dairy cattle. Procedures developed permit relatively rapid and accurate determination of somatic cell counts in milk of mice. Concentration of somatic cells was three to four times greater in mice than in dairy cows, but counts were distributed similarly. A large effect for stage of lactation existed with high counts in late lactation. Within lactation, repeatability of somatic cell counts and relationships between somatic cell counts and milk yield were similar to those reported for dairy cattle. Heritability of lactation average somatic cell count (3 sample d, log base 2, adjusted for stage of lactation) was .24, indicating lines genetically divergent for somatic cell count can be developed.
对实验小鼠乳汁中体细胞数增加和减少进行双向选择的初步结果，被用于评估实验小鼠作为研究奶牛产奶量与体细胞数关系的模式生物的实用性。所制定的程序能够相对快速且准确地测定小鼠乳汁中的体细胞数。小鼠体细胞的浓度是奶牛的三到四倍，但细胞数的分布相似。泌乳阶段影响很大，泌乳后期体细胞数较高。在泌乳期内，体细胞数的重复性以及体细胞数与产奶量之间的关系与奶牛的报道相似。泌乳期平均体细胞数（3个样本，以2为底的对数，根据泌乳阶段进行调整）的遗传力为0.24，这表明可以培育出体细胞数存在遗传差异的品系。
