Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
National Health Commission Key Laboratory of Prevention and Treatment of Cerebrovascular Diseases, Beijing, China.
Curr Neurovasc Res. 2023;20(2):175-182. doi: 10.2174/1567202620666230524155702.
Cerebral small vessel disease (CSVD) refers to a common cerebrovascular disease and white matter hyperintensities (WMHs) constitute a typical feature of CSVD. However, there has not been a large number of studies investigating the relationship between lipid profile components and WMHs.
Altogether, 1019 patients with CSVD were enrolled at the First Affiliated Hospital of Zhengzhou University between April 2016 to December 2021. Baseline data were collected for all patients, including demographic characteristics and clinical data. WMH volumes were evaluated by two experienced neurologists using the MRIcro software. Multivariate regression analysis was used to investigate the relationship among the severity of WMHs, blood lipids and common risk factors.
Altogether, 1019 patients with CSVD were enrolled, including 255 in the severe WMH group and 764 in the mild WMH group. After including age, sex and blood lipids to construct a multivariate logistic regression equation, we observed that the severity of WMHs was independently predicted by low-density lipoprotein (LDL), homocysteine level and history of cerebral infarction.
We used WMH volume, a highly accurate measure, to assess its relationship with lipid profiles. The WMH volume increased with a decrease in LDL. This relationship was more significant, especially among the subgroups of patients aged <70 years and men. Patients with cerebral infarction and higher homocysteine levels were more likely to have higher WMH volumes. Our study has provided a reference for clinical diagnosis and therapy, especially for discussing the role of blood lipid profiles in the pathophysiology of CSVD.
脑小血管病（CSVD）是一种常见的脑血管病，脑白质高信号（WMHs）构成 CSVD 的典型特征。然而，目前还没有大量研究探讨血脂成分与 WMHs 之间的关系。
本研究共纳入 2016 年 4 月至 2021 年 12 月在郑州大学第一附属医院就诊的 1019 例 CSVD 患者。收集所有患者的基线数据，包括人口统计学特征和临床资料。WMH 体积由 2 名经验丰富的神经科医生使用 MRIcro 软件进行评估。采用多变量回归分析探讨 WMHs 严重程度、血脂与常见危险因素之间的关系。
共纳入 1019 例 CSVD 患者，其中重度 WMH 组 255 例，轻度 WMH 组 764 例。纳入年龄、性别和血脂后构建多变量逻辑回归方程，结果发现 WMHs 严重程度与 LDL、同型半胱氨酸水平和脑梗死史独立相关。
我们使用 WMH 体积这一高度准确的指标来评估其与血脂谱的关系。WMH 体积随 LDL 降低而增加，这种关系在年龄<70 岁和男性亚组中更为显著。脑梗死和同型半胱氨酸水平较高的患者 WMH 体积较高。本研究为临床诊断和治疗提供了参考，特别是为探讨血脂谱在 CSVD 病理生理学中的作用提供了参考。
