Department of Biological and Environmental Sciences and Technology, University of Salento, Lecce, Italy.
Institute of Clinical Physiology, National Research Council, Branch of Lecce, Lecce, Italy.
Curr HIV Res. 2023;21(2):128-139. doi: 10.2174/1570162X21666230524151328.
Increasing evidence suggests that microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) have emerged as attractive targets in viral infections, including Human immunodeficiency virus (HIV).
To deepen the understanding of the molecular mechanisms that lead to HIV and provide potential targets for the future development of molecular therapies for its treatment.
Four miRNAs were selected as candidates based on a previous systematic review. A combination of bioinformatic analyses was performed to identify their target genes, lncRNAs and biological processes that regulate them.
In the constructed miRNA-mRNA network, 193 gene targets are identified. These miRNAs potentially control genes from several important processes, including signal transduction and cancer. LncRNA-XIST, lncRNA-NEAT1 and lncRNA-HCG18 interact with all four miRNAs.
This preliminary result forms the basis for improving reliability in future studies to fully understand the role these molecules and their interactions play in HIV.
越来越多的证据表明，微小 RNA（miRNA）和长链非编码 RNA（lncRNA）已成为病毒感染（包括人类免疫缺陷病毒（HIV））的有吸引力的靶点。
深入了解导致 HIV 的分子机制，并为未来开发针对 HIV 的分子治疗方法提供潜在靶点。
根据先前的系统评价，选择了 4 个 miRNA 作为候选物。进行了组合生物信息学分析，以鉴定它们的靶基因、lncRNA 和调节它们的生物学过程。
在构建的 miRNA-mRNA 网络中，鉴定出 193 个基因靶标。这些 miRNA 可能控制包括信号转导和癌症在内的几个重要过程中的基因。lncRNA-XIST、lncRNA-NEAT1 和 lncRNA-HCG18 与所有 4 个 miRNA 相互作用。
这一初步结果为提高未来研究的可靠性奠定了基础，以充分了解这些分子及其相互作用在 HIV 中所起的作用。
