ω-3 脂肪酸作为神经性厌食症患者治疗饮食和心理症状的辅助剂：系统评价和荟萃分析。

Omega-3 as an adjuvant in the treatment eating and psychological symptoms in patients with anorexia nervosa: a systematic review and meta-analyses.

机构信息

Translational Biomedicine Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil.

Laboratory of Evidence-Based Practice, Universidade Estadual de Mato Grosso do Sul, Campo Grande, MS, Brazil.

出版信息

J Hum Nutr Diet. 2023 Oct;36(5):1970-1981. doi: 10.1111/jhn.13187. Epub 2023 Jun 6.

DOI:10.1111/jhn.13187

PMID:37226879

Abstract

BACKGROUND

This study was carried out to assess the effects of omega-3 supplementation as an adjunct treatment for eating and psychological symptoms in patients with anorexia nervosa.

METHODS

We conducted a systematic review of the literature using the terms 'anorexia nervosa' AND 'Fatty Acids, Omega-3'. Five randomised controlled trials with a total of 144 participants, published between 2003 and 2022, were included.

RESULTS

The effects of supplementation of omega-3 on anxiety were standardised mean difference (SMD) 0.79, 95% confidence interval (CI) -0.08 to 1.66; p = 0.08; I² = 3%; two studies, 33 participants; moderate quality of evidence. For depression, the supplementation of omega-3 was SMD: 0.22, 95% CI: -0.50 to 0.93; p = 0.18; I² = 45%; two studies, 33 participants; moderate quality of evidence. For obsessive-compulsive disorder, the supplementation of omega-3 was SMD: -0.22, 95% CI: -0.70 to 2.25; p = 0.36; I² = 0%; three studies, 32 participants; low quality of evidence.

CONCLUSION

This research showed that regardless of dose, time or, if associated with other components, the use of omega-3 supplementations as an adjuvant treatment showed no evidence of effect in eating and psychological symptoms in patients with anorexia nervosa.

摘要

背景

本研究旨在评估ω-3 补充剂作为辅助治疗对神经性厌食症患者的进食和心理症状的影响。

方法

我们使用术语“神经性厌食症”和“脂肪酸，ω-3”进行了文献系统评价。纳入了五项随机对照试验，共有 144 名参与者，发表于 2003 年至 2022 年之间。

结果

ω-3 补充剂对焦虑的影响的标准化均数差（SMD）为 0.79，95%置信区间（CI）为-0.08 至 1.66；p=0.08；I²=3%；两项研究，33 名参与者；中等质量证据。对于抑郁，ω-3 补充剂的 SMD 为：0.22，95%CI：-0.50 至 0.93；p=0.18；I²=45%；两项研究，33 名参与者；中等质量证据。对于强迫症，ω-3 补充剂的 SMD 为：-0.22，95%CI：-0.70 至 2.25；p=0.36；I²=0%；三项研究，32 名参与者；低质量证据。