Gettes D R, Faber J E, Velandia N B
J Auton Nerv Syst. 1986 Jun;16(2):101-8. doi: 10.1016/0165-1838(86)90002-0.
The purpose of this study was to determine whether renal innervation is required for compensatory growth of the remaining kidney following unilateral nephrectomy. In the first study, young (6-week-old) rats were divided into 4 groups and the following surgical procedures were performed. Group 1 animals had their left and right kidneys removed and weighed to provide a measure of control weight prior to compensatory growth. Group 2 and 3 animals underwent right nephrectomy, followed by left kidney denervation (Group 2) or sham denervation (Group 3). Animals from Group 4 were subjected to right sham nephrectomy and sham denervation of the left kidneys. Three weeks later, animals from Groups 2, 3 and 4 were sacrificed and left kidneys were weighed. Relative to control kidney weight (Group 1), left kidney weight increased over 3 weeks by 92% when both kidneys were present (Group 4), representing normal renal growth. Animals with prior nephrectomy but intact renal innervation (Group 3) demonstrated an additional increase in kidney weight of 74% over the same interval, representing compensatory growth. Prior denervation of the left kidney (Group 2) had no effect on the degree of compensatory growth whether expressed in absolute kidney weight or relative to body weight. A second study was performed to determine whether renal innervation influences the initial state of compensatory growth when measured at an earlier time after unilateral nephrectomy. One week after right nephrectomy, left kidney weight was similar in animals with sham left renal denervation (1.08 +/- 0.04 g) when compared to animals with left renal denervation (1.06 +/- 0.02 g). Thus, for a least young rats, renal innervation is not required for full compensatory renal growth following unilateral nephrectomy.
本研究的目的是确定单侧肾切除术后，剩余肾脏的代偿性生长是否需要肾神经支配。在第一项研究中，将年轻（6周龄）大鼠分为4组，并进行了以下手术操作。第1组动物切除左、右肾并称重，以提供代偿性生长前的对照重量测量值。第2组和第3组动物接受右肾切除术，随后第2组进行左肾去神经支配，第3组进行假去神经支配。第4组动物接受右假肾切除术和左肾假去神经支配。三周后，处死第2、3和4组的动物并对左肾称重。相对于对照肾重量（第1组），当双侧肾脏都存在时（第4组），左肾重量在3周内增加了92%，代表正常肾脏生长。先前接受肾切除术但肾神经支配完整的动物（第3组）在相同时间段内肾脏重量额外增加了74%，代表代偿性生长。左肾预先去神经支配（第2组）对代偿性生长程度没有影响，无论是以绝对肾重量还是相对于体重来表示。进行了第二项研究，以确定在单侧肾切除术后更早时间测量时，肾神经支配是否影响代偿性生长的初始状态。右肾切除术后一周，假左肾去神经支配的动物（1.08±0.04 g）与左肾去神经支配的动物（1.06±0.02 g）相比，左肾重量相似。因此，至少对于年轻大鼠来说，单侧肾切除术后肾脏的完全代偿性生长不需要肾神经支配。
