登上瓣膜健康的 escalator。

Riding up the escaLEC-TOR for valvular health.

机构信息

Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA, USA.

出版信息

J Cell Biol. 2023 Jun 5;222(6). doi: 10.1083/jcb.202305005. Epub 2023 May 25.

DOI:10.1083/jcb.202305005

PMID:37227450

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10225616/

Abstract

Endothelial-lined valves assure unidirectional flow in the lymphatic system. In this issue, Saygili Demir et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202207049) demonstrate how continuous repair of these valves occur, beginning with mTOR-activated cell replication in valve sinuses, and followed by cell migration to cover the valve surface.

摘要

内皮衬里的瓣膜确保了淋巴系统中的单向流动。在本期杂志中，Saygili Demir 等人（2023.《细胞生物学杂志》，https://doi.org/10.1083/jcb.202207049）展示了这些瓣膜是如何持续修复的，首先是在瓣膜窦中激活 mTOR 的细胞复制，然后是细胞迁移以覆盖瓣膜表面。