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采用血小板功能分析的血栓弹力图指导血小板无力症患者急诊剖宫产麻醉管理:一例报告

Thromboelastography with platelet mapping to guide anesthetic management of emergency cesarean delivery in a patient with thrombasthenia: a case report.

作者信息

Akinaga Chieko, Kawashima Shingo, Suzuki Yuji, Matsumoto Masako, Nakajima Yoshiki

机构信息

Department of Anesthesiology and Intensive Care Medicine, Hamamatsu University Hospital, 1-20-1 Handayama, Higashi-Ku, Hamamatsu-Shi, Shizuoka, 431-3192, Japan.

Department of Obstetrics and Gynecology, Hamamatsu University Hospital, Hamamatsu, Japan.

出版信息

JA Clin Rep. 2023 May 25;9(1):30. doi: 10.1186/s40981-023-00623-x.

Abstract

BACKGROUND

Perinatal management of congenital platelet dysfunction represents a challenge. One of the major concerns is whether neuraxial anesthesia can be applicable for cesarean delivery. We present a patient with thrombasthenia who underwent emergency cesarean delivery.

CASE PRESENTATION

A 34-year-old primipara was diagnosed with autosomal dominant thrombasthenia, which was not classified as any known type. A thorough examination revealed that adenosine diphosphate aggregation and collagen aggregation were suppressed. Platelet mapping of viscoelastic testing was used to observe the trajectory of platelet function during pregnancy, which was found to be normal to hypercoagulable until 38 weeks of gestation. On the basis of the results of testing and physiological status, we commenced spinal anesthesia and avoided prophylactic platelet transfusion.

CONCLUSION

The platelet mapping of viscoelastic testing was rapid and simple, allowing repeated examinations. We could choose the appropriate anesthesia method and determine the necessity of blood transfusion for a pregnant patient with thrombasthenia.

摘要

背景

先天性血小板功能障碍的围产期管理是一项挑战。主要担忧之一是神经轴索麻醉是否适用于剖宫产。我们报告一例血小板无力症患者接受急诊剖宫产的情况。

病例介绍

一名34岁初产妇被诊断为常染色体显性血小板无力症,不属于任何已知类型。全面检查显示二磷酸腺苷聚集和胶原聚集均受抑制。采用粘弹性检测的血小板功能图谱观察孕期血小板功能轨迹,发现直至妊娠38周均正常至高凝状态。根据检测结果和生理状况,我们实施了脊髓麻醉并避免预防性血小板输注。

结论

粘弹性检测的血小板功能图谱快速且简便,允许重复检查。我们能够为血小板无力症的孕妇选择合适的麻醉方法并确定输血的必要性。

相似文献

2
Peripartum management of a patient with Glanzmann's thrombasthenia using Thrombelastograph.
Br J Anaesth. 2002 May;88(5):734-8. doi: 10.1093/bja/88.5.734.

本文引用的文献

6
Thrombocytopenia and disorders of platelet function in pregnancy.妊娠期间的血小板减少症和血小板功能障碍。
Semin Thromb Hemost. 2011 Sep;37(6):640-52. doi: 10.1055/s-0031-1291374. Epub 2011 Nov 18.
7
Peripartum management of a patient with Glanzmann's thrombasthenia using Thrombelastograph.
Br J Anaesth. 2002 May;88(5):734-8. doi: 10.1093/bja/88.5.734.

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