Centre for Proton Therapy, Paul Scherrer Institute, Villigen PSI, Switzerland.
Department of Physics, ETH Zurich, Zurich, Switzerland.
Med Phys. 2023 Sep;50(9):5828-5841. doi: 10.1002/mp.16464. Epub 2023 May 25.
Experiments with ultra-high dose rates in proton therapy are of increasing interest for potential treatment benefits. The Faraday Cup (FC) is an important detector for the dosimetry of such ultra-high dose rate beams. So far, there is no consensus on the optimal design of a FC, or on the influence of beam properties and magnetic fields on shielding of the FC from secondary charged particles.
To perform detailed Monte Carlo simulations of a Faraday cup to identify and quantify all the charge contributions from primary protons and secondary particles that modify the efficiency of the FC response as a function of a magnetic field employed to improve the detector's reading.
In this paper, a Monte Carlo (MC) approach was used to investigate the Paul Scherrer Institute (PSI) FC and quantify contributions of charged particles to its signal for beam energies of 70, 150, and 228 MeV and magnetic fields between 0 and 25 mT. Finally, we compared our MC simulations to measurements of the response of the PSI FC.
For maximum magnetic fields, the efficiency (signal of the FC normalized to charged delivered by protons) of the PSI FC varied between 99.97% and 100.22% for the lowest and highest beam energy. We have shown that this beam energy-dependence is mainly caused by contributions of secondary charged particles, which cannot be fully suppressed by the magnetic field. Additionally, it has been demonstrated that these contributions persist, making the FC efficiency beam energy dependent for fields up to 250 mT, posing inevitable limits on the accuracy of FC measurements if not corrected. In particular, we have identified a so far unreported loss of electrons via the outer surfaces of the absorber block and show the energy distributions of secondary electrons ejected from the vacuum window (VW) (up to several hundred keV), together with electrons ejected from the absorber block (up to several MeV). Even though, in general, simulations and measurements were well in agreement, the limitation of the current MC calculations to produce secondary electrons below 990 eV posed a limit in the efficiency simulations in the absence of a magnetic field as compared to the experimental data.
TOPAS-based MC simulations allowed to identify various and previously unreported contributions to the FC signal, which are likely to be present in other FC designs. Estimating the beam energy dependence of the PSI FC for additional beam energies could allow for the implementation of an energy-dependent correction factor to the signal. Dose estimates, based on accurate measurements of the number of delivered protons, provided a valid instrument to challenge the dose determined by reference ionization chambers, not only at ultra-high dose rates but also at conventional dose rates.
质子治疗中超高剂量率实验因其潜在的治疗益处而受到越来越多的关注。法拉第杯(FC)是一种用于超高剂量率束剂量测量的重要探测器。到目前为止,对于 FC 的最佳设计,或者对于束特性和磁场对 FC 免受二次带电粒子屏蔽的影响,尚无共识。
对法拉第杯进行详细的蒙特卡罗模拟,以确定和量化主要质子和二次粒子的所有电荷贡献,这些贡献会改变 FC 响应的效率,作为一种用于提高探测器读数的磁场的函数。
在本文中,采用蒙特卡罗(MC)方法研究了保罗谢勒研究所(PSI)的法拉第杯,并量化了在 70、150 和 228 MeV 束能和 0 至 25 mT 之间的磁场下,带电粒子对其信号的贡献。最后,我们将我们的 MC 模拟与 PSI FC 响应的测量结果进行了比较。
对于最大磁场,PSI FC 的效率(FC 的信号与质子传递的电荷量之比)对于最低和最高束能分别在 99.97%和 100.22%之间变化。我们已经表明,这种束能依赖性主要是由二次带电粒子的贡献引起的,而磁场并不能完全抑制这些贡献。此外,还表明,这些贡献仍然存在,使得 FC 效率在高达 250 mT 的磁场下仍然依赖于束能,如果不进行校正,则会对 FC 测量的准确性造成不可避免的限制。特别是,我们已经确定了一个迄今为止未报告的通过吸收块的外表面损失电子的情况,并显示了从真空窗(VW)中射出的二次电子(高达几百 keV)以及从吸收块中射出的电子的能量分布(高达几 MeV)。尽管一般来说,模拟和测量结果非常吻合,但当前 MC 计算在没有磁场的情况下将二次电子产生到 990 eV 以下的限制,使得在缺乏磁场的情况下,与实验数据相比,效率模拟存在限制。
基于 TOPAS 的 MC 模拟允许确定 FC 信号的各种以前未报告的贡献,这些贡献可能存在于其他 FC 设计中。对于其他束能,估计 PSI FC 的束能依赖性可以为信号实施能量相关的校正因子。基于对传递的质子数的准确测量的剂量估计,为参考电离室确定的剂量提供了一个有效的工具,不仅在超高剂量率下,而且在常规剂量率下也是如此。