Ponnaboina Divya Madhuri, Perumandal Sushmitha, I Sreelakshmi
Pathology, Osmania Medical College, Hyderabad, IND.
Cureus. 2023 Apr 23;15(4):e38018. doi: 10.7759/cureus.38018. eCollection 2023 Apr.
Urothelial carcinomas account for the majority of all primary bladder cancers, making bladder cancer the second most frequent genitourinary malignancy after prostate cancer. Bladder cancer risk rises with age and most of them return after resection due to their multifocal distribution, and they often develop in superficial locations. Like many other cancers, bladder carcinoma is associated with a few tumor markers that have been evaluated in the past. They include p53, p63, and HER2. This study was conducted on 88 patients suspected of urinary bladder carcinoma. This prospective study was done at the Department of Pathology, Osmania General Hospital, Hyderabad from August 2017 to July 2019. Of the 88 patients, 76 were diagnosed with bladder carcinoma and the remaining 12 were non-neoplastic. The primary neoplastic lesions of the urinary bladder were predominantly seen in patients older than 40 years and were found to be statistically significant (p<0.01). Of the 34 cases of high-grade papillary urothelial carcinoma (PUC), 26 (76.47%) were males, eight cases (23.53%) were females, while among the 25 cases of low-grade PUC, 20 cases (80%) were males, and five cases (20%) were females. In seven cases of squamous cell carcinoma, six cases (85.71%) were males and only one case (14.29%) was female. Of the two cases of adenocarcinoma, male and female gender accounted for one case each (50%). The two cases of papillary urothelial neoplasm of low malignant potential were males in the study. On the whole, the primary urinary bladder lesions are more predominant in the males (77.63%) than the females (22.37%). Overexpression of p53 is negatively connected to p63 expression, and HER2 and p53 were strongly associated with high tumor grade in urothelial carcinoma.
尿路上皮癌占所有原发性膀胱癌的大多数，使得膀胱癌成为仅次于前列腺癌的第二常见泌尿生殖系统恶性肿瘤。膀胱癌风险随年龄增长而升高，并且由于其多灶性分布，大多数在切除后会复发，且它们常发生于浅表部位。与许多其他癌症一样，膀胱癌与过去已评估的一些肿瘤标志物有关。它们包括p53、p63和HER2。本研究对88例疑似膀胱癌患者进行。这项前瞻性研究于2017年8月至2019年7月在海得拉巴奥斯曼尼亚总医院病理科进行。88例患者中，76例被诊断为膀胱癌，其余12例为非肿瘤性病变。膀胱原发性肿瘤性病变主要见于40岁以上患者，且具有统计学意义（p<0.01）。在34例高级别乳头状尿路上皮癌（PUC）中，26例（76.47%）为男性，8例（23.53%）为女性，而在25例低级别PUC中，20例（80%）为男性，5例（20%）为女性。在7例鳞状细胞癌中，6例（85.71%）为男性，仅1例（14.29%）为女性。在2例腺癌中，男性和女性各占1例（50%）。本研究中2例低恶性潜能乳头状尿路上皮肿瘤均为男性。总体而言，膀胱原发性病变在男性（77.63%）中比女性（22.37%）更常见。p53的过表达与p63表达呈负相关，且HER2和p53与尿路上皮癌的高肿瘤分级密切相关。
