Fuse Y, Hosono Y, Kakinuma S
Nihon Sanka Fujinka Gakkai Zasshi. 1986 May;38(5):643-6.
In order to approach from the aspect of blood coagulation and fibrinolysis the reason for the birth of SGA (small for gestational age) infants, we studied the blood coagulation and fibrinolysis capacity of maternal venous blood in the 36th and 37th weeks after conception employing 54 cases in which were no abnormality was seen during pregnancy up to delivery, and we also studied the relationship of the body weight at delivery and arrived at the following conclusions. In the SGA infant birth group there was a tendency toward acceleration of blood coagulation, acceleration of blood platelet aggregation and inhibition of fibrinolysis when compared with two other groups i.e. AGA (appropriate for gestational age) and LGA (large for gestational age) infant birth groups. In the SGA infant birth group in particular there was seen a statistically significant reduction in prothrombin time (p less than 0.002) when compared with the other two groups. A correlation was noted between prothrombin time for maternal blood and the infant's body weight at birth (r = 0.38446, p less than 0.01), and the shorter the prothrombin time for maternal blood in the late stage of pregnancy, the lower the infant's body weight tended to be at birth. The results indicate that these changes in blood coagulation and fibrinolysis may influence the decrease in the blood output of the uterine placenta, and it may be assumed that this causes the birth of SGA infants. Furthermore, the prothrombin time values become one of the parameters used in forecasting an SGA infant's birth, and this should to be considered as a new fibrinolytic therapy for SGA infants.
为了从血液凝固和纤维蛋白溶解方面探讨小于胎龄儿（SGA）出生的原因，我们研究了受孕后第36和37周时54例孕期直至分娩均无异常的孕妇静脉血的血液凝固和纤维蛋白溶解能力，并研究了分娩时体重的关系，得出以下结论。与另外两组即适于胎龄儿（AGA）和大于胎龄儿（LGA）出生组相比，SGA婴儿出生组有血液凝固加速、血小板聚集加速和纤维蛋白溶解受抑制的倾向。特别是与其他两组相比，SGA婴儿出生组的凝血酶原时间有统计学意义的降低（p<0.002）。孕妇血液的凝血酶原时间与婴儿出生体重之间存在相关性（r = 0.38446，p<0.01），孕期晚期孕妇血液的凝血酶原时间越短，婴儿出生体重往往越低。结果表明，这些血液凝固和纤维蛋白溶解的变化可能影响子宫胎盘的血流量减少，并且可以假定这导致了SGA婴儿的出生。此外，凝血酶原时间值成为预测SGA婴儿出生的参数之一，并且这应被视为SGA婴儿的一种新的纤维蛋白溶解疗法。
