Ikai T
Nihon Seikeigeka Gakkai Zasshi. 1986 Feb;60(2):161-73.
I examined the effect of Marcain on the intact and skinned muscle fibers. The whole extensor digitorum longus muscle of rats was mounted in a small bath containing Krebs-Ringer solution. Marcain, when added to the incubation medium, produced a large contracture and markedly increased release of creatine kinase. But the contracture and the release of CK were suppressed with the omission of Ca ion. On pathological examinations of muscle incubated in Marcain solution, muscle fibers were hypercontracted. On the electron microscopy, the sarcomere was shortened and Z-line was partly obscure. The plasmalemma was focally disrupted. In the study on the skinned fiber, Marcain mainly interfered the function of the sarcoplasmic reticulum. Activity of the Ca uptake was inhibited. Ca-induced Ca release and leakage of Ca were facilitated. It was concluded from the present study that regulation of intracellular Ca ion was disturbed by Marcain, causing acute rhabdomyolysis.
我研究了甲哌卡因对完整和去膜肌纤维的影响。将大鼠的整个趾长伸肌置于含有 Krebs-Ringer 溶液的小浴槽中。当将甲哌卡因添加到孵育培养基中时，会产生大量挛缩并显著增加肌酸激酶的释放。但是，当省略钙离子时，挛缩和肌酸激酶的释放受到抑制。对在甲哌卡因溶液中孵育的肌肉进行病理检查时，肌纤维过度收缩。在电子显微镜下，肌节缩短，Z 线部分模糊不清。质膜有局灶性破坏。在对去膜纤维的研究中，甲哌卡因主要干扰肌浆网的功能。钙摄取活性受到抑制。钙诱导的钙释放和钙泄漏增加。从本研究得出的结论是，甲哌卡因扰乱了细胞内钙离子的调节，导致急性横纹肌溶解。
