桔霉素作为一种潜在的抗癌疗法：全面综述。

Citrinin as a potential anti-cancer therapy: A comprehensive review.

机构信息

Laboratory of Genetical Toxicology, Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64, 049-550, Brazil.

Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.

出版信息

Chem Biol Interact. 2023 Aug 25;381:110561. doi: 10.1016/j.cbi.2023.110561. Epub 2023 May 23.

DOI:10.1016/j.cbi.2023.110561

PMID:37230156

Abstract

Citrinin (CIT) is a polyketide-derived mycotoxin, which is produced by many fungal strains belonging to the gerena Monascus, Aspergillus, and Penicillium. It has been postulated that mycotoxins have several toxic mechanisms and are potentially used as antineoplastic agents. Therefore, the present study carried out a systematic review, including articles from 1978 to 2022, by collecting evidence in experimental studies of CIT antiplorifactive activity in cancer. The Data indicate that CIT intervenes in important mediators and cell signaling pathways, including MAPKs, ERK1/2, JNK, Bcl-2, BAX, caspases 3,6,7 and 9, p53, p21, PARP cleavage, MDA, reactive oxygen species (ROS) and antioxidant defenses (SOD, CAT, GST and GPX). These factors demonstrate the potential antitumor drug CIT in inducing cell death, reducing DNA repair capacity and inducing cytotoxic and genotoxic effects in cancer cells.

摘要

桔青霉素（CIT）是一种多酮衍生的真菌毒素，由许多真菌菌株产生，属于红曲霉属、曲霉属和青霉属。据推测，真菌毒素具有多种毒性机制，并可能被用作抗肿瘤药物。因此，本研究通过收集 1978 年至 2022 年的实验研究证据，对 CIT 在癌症中的抗增殖活性进行了系统综述。数据表明，CIT 干预了重要的介质和细胞信号通路，包括 MAPKs、ERK1/2、JNK、Bcl-2、BAX、caspases 3、6、7 和 9、p53、p21、PARP 裂解、MDA、活性氧（ROS）和抗氧化防御（SOD、CAT、GST 和 GPX）。这些因素表明，CIT 作为一种潜在的抗肿瘤药物，能够诱导细胞死亡，降低 DNA 修复能力，并在癌细胞中诱导细胞毒性和遗传毒性作用。