State Key Laboratory of Systems Medicine for Cancer, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai Cancer Institute, Shanghai, China.
Gut Microbes. 2024 Jan-Dec;16(1):2328868. doi: 10.1080/19490976.2024.2328868. Epub 2024 Mar 14.
The role of gut fungal species in tumor-related processes remains largely unexplored, with most studies still focusing on fungal infections. This review examines the accumulating evidence suggesting the involvement of commensal and pathogenic fungi in cancer biological process, including oncogenesis, progression, and treatment response. Mechanisms explored include fungal influence on host immunity, secretion of bioactive toxins/metabolites, interaction with bacterial commensals, and migration to other tissues in certain types of cancers. Attempts to utilize fungal molecular signatures for cancer diagnosis and fungal-derived products for treatment are discussed. A few studies highlight fungi's impact on the responsiveness and sensitivity to chemotherapy, radiotherapy, immunotherapy, and fecal microbiota transplant. Given the limited understanding and techniques in fungal research, the studies on gut fungi are still facing great challenges, despite having great potentials.
肠道真菌物种在肿瘤相关过程中的作用在很大程度上仍未得到探索，大多数研究仍集中于真菌感染。本综述检查了越来越多的证据，这些证据表明共生和病原真菌参与了癌症的生物学过程，包括肿瘤发生、进展和治疗反应。探讨的机制包括真菌对宿主免疫的影响、生物活性毒素/代谢物的分泌、与细菌共生体的相互作用以及在某些类型癌症中向其他组织的迁移。还讨论了利用真菌分子特征进行癌症诊断和真菌衍生产品进行治疗的尝试。一些研究强调了真菌对化疗、放疗、免疫疗法和粪便微生物移植的反应性和敏感性的影响。考虑到真菌研究中的技术和理解有限，尽管具有巨大的潜力，但肠道真菌的研究仍面临巨大挑战。
