欧盟 15 国的阑尾炎死亡率、发病率和伤残调整生命年趋势：1990-2019 年全球疾病负担数据库的观察性研究。

Trends in the mortality, incidence and disability-adjusted life-years of appendicitis in EU15+ countries: an observational study of the Global Burden of Disease Database, 1990-2019.

机构信息

Imperial College Healthcare NHS Trust.

Imperial College London, London.

出版信息

Int J Surg. 2023 Sep 1;109(9):2608-2613. doi: 10.1097/JS9.0000000000000499.

DOI:10.1097/JS9.0000000000000499

PMID:37232122

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10498886/

Abstract

BACKGROUND

Appendicitis places a substantial burden on healthcare systems, with acute appendicitis alone being the most common abdominal surgical emergency worldwide. Further characterisation of the disease burden in EU15+ countries may help optimise the distribution of healthcare resources. The aim of this observational study was to assess the trends in mortality, incidence and disability-adjusted life-years (DALYs) of appendicitis across European Union (EU) 15+ countries between the years 1990 and 2019, Supplemental Digital Content 3, http://links.lww.com/JS9/A589 .

MATERIALS AND METHODS

Age-standardised mortality rates (ASMRs), age-standardised incidence rates (ASIRs) and DALYs data for appendicitis in males and females were extracted from the 2019 Global Burden of Disease (GBD) study. Temporal trends within the study period were analysed using Joinpoint regression analysis.

RESULTS

The median ASMRs across EU15+ countries in 2019 were 0.08/100 000 and 0.13/100 000 for females and males, respectively. Between 1990 and 2019 the median percentage change in ASMR was -52.12% for females and -53.18% in males. The median ASIRs in 2019 for females and males were 251/100 000 and 278/100 000, respectively, with a median percentage change of +7.22% for females and +3.78% for males during the observation period. Decreasing trends in DALYs were observed over the 30-year study period, with median percentage changes of -23.57% and -33.81% for females and males, respectively, Supplemental Digital Content 3, http://links.lww.com/JS9/A589 .

CONCLUSION

Overall, a general trend of decreasing appendicitis ASMRs and DALYs was observed across EU15+ countries, despite small overall increases in appendicitis ASIRs, Supplemental Digital Content 3, http://links.lww.com/JS9/A589 . Variations in both diagnostic and management strategies over the study period are likely contributory to the changing trends.

摘要

背景

阑尾炎给医疗系统带来了巨大负担，仅急性阑尾炎就是全球最常见的腹部外科急症。进一步描述欧盟 15 国以上国家的疾病负担情况，可能有助于优化医疗资源的分配。本观察性研究旨在评估 1990 年至 2019 年期间欧盟 15 国以上国家阑尾炎的死亡率、发病率和伤残调整生命年（DALY）趋势，补充数字内容 3，http://links.lww.com/JS9/A589。

材料和方法

从 2019 年全球疾病负担（GBD）研究中提取了男性和女性阑尾炎的年龄标准化死亡率（ASMR）、年龄标准化发病率（ASIR）和 DALY 数据。使用 Joinpoint 回归分析对研究期间的时间趋势进行了分析。

结果

2019 年欧盟 15 国以上国家的中位数 ASMR 分别为女性 0.08/100000 和男性 0.13/100000。1990 年至 2019 年期间，女性 ASMR 的中位数百分比变化为-52.12%，男性为-53.18%。2019 年女性和男性的中位数 ASIR 分别为 251/100000 和 278/100000，在此期间，女性的中位数百分比变化为+7.22%，男性为+3.78%。在 30 年的研究期间，DALY 呈下降趋势，女性和男性的中位数百分比变化分别为-23.57%和-33.81%，补充数字内容 3，http://links.lww.com/JS9/A589。