Boros S J, Mammel M C, Lewallen P K, Coleman J M, Gordon M J, Ophoven J
J Pediatr. 1986 Jul;109(1):95-100. doi: 10.1016/s0022-3476(86)80585-6.
The tracheobronchial histopathologic findings in eight neonates who died after treatment with high-frequency jet ventilation (HFJV) were compared with those in eight similar infants who died after treatment with conventional mechanical ventilation. The HFJV and conventionally treated groups were matched as closely as possible for birth weight, gestational age, and duration of mechanical ventilation. A 4-point, nine-variable histologic scoring system was used to grade tissue changes in the trachea, carina, and mainstem bronchi. The patients who received HFJV had significantly more histologic damage in their tracheas, carinas, and right and left mainstem bronchi. At all levels of the airway examined, HFJV was associated with more inflammation, greater losses of ciliated epithelium, and more mucus within the lumen of the airway than was conventional mechanical ventilation.
将接受高频喷射通气（HFJV）治疗后死亡的8例新生儿的气管支气管组织病理学结果，与接受传统机械通气治疗后死亡的8例类似婴儿的结果进行了比较。HFJV组和传统治疗组在出生体重、胎龄和机械通气持续时间方面尽可能进行了匹配。采用一个4分、9变量的组织学评分系统对气管、隆突和主支气管的组织变化进行分级。接受HFJV治疗的患者在其气管、隆突以及左右主支气管中出现的组织学损伤明显更多。在检查的气道所有水平上，与传统机械通气相比，HFJV与更多的炎症、纤毛上皮的更大损失以及气道腔内更多的黏液有关。
