碱性溶剂类型和pH值对来自……的卡拉胶固体物理性质的影响

Effects of Alkaline Solvent Type and pH on Solid Physical Properties of Carrageenan from .

作者信息

Ferdiansyah Rival, Abdassah Marline, Zainuddin Achmad, Rachmaniar Revika, Chaerunisaa Anis Yohana

机构信息

Doctoral Program, Faculty of Pharmacy, Padjadjaran University, Jl. Raya Bandung-Sumedang KM 21, Jatinangor 45363, West Java, Indonesia.

Department of Pharmaceutics, Sekolah Tinggi Farmasi Indonesia, Jl. Soekarno-Hatta No. 354, Bandung 40266, West Java, Indonesia.

出版信息

Gels. 2023 May 10;9(5):397. doi: 10.3390/gels9050397.

DOI:10.3390/gels9050397

PMID:37232989

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10217466/

Abstract

The effects of alkali type and pH on the physical properties of carrageenan have been extensively studied. However, their effects on certain characteristics of solid-state properties of carrageenan have not been identified. This research aimed to investigate the effect of alkaline solvent type and pH on the solid physical properties of carrageenan isolated from . Carrageenan was extracted from the algae using NaOH, KOH, and Ca(OH) at pHs of 9, 11, and 13. Based on the results of preliminary characterization, including yield, ash content, pH, sulphate content, viscosity, and gel strength, it was found that all samples followed Food and Agriculture Organization (FAO) specifications. The swelling capacity of carrageenan based on the type of alkali was KOH > NaOH > Ca(OH). The FTIR spectra of all samples were in agreement with that of standard carrageenan. The molecular weight (MW) of carrageenan using KOH as the alkali followed the order pH 13 > pH 9 > pH 11, while using NaOH, the order was pH 9 > pH 13 > pH 11, and while using Ca(OH), the order was pH 13 > pH 9 > pH 11. The results of the solid-state physical characterization of carrageenan with the highest MW in each type of alkali showed that the morphology of carrageenan using Ca(OH) has a cubic shape and is more crystal-like. The order of crystallinity of carrageenan using different types of alkali was Ca(OH) (14.44%) > NaOH (9.80%) > KOH (7.91%), while the order of density was Ca(OH) > KOH > NaOH. The order of solid fraction (SF) of the carrageenan was KOH > Ca(OH) > NaOH, while the tensile strength when using KOH was 1.17, when using NaOH it was 0.08, and while using Ca(OH), it was 0.05. The bonding index (BI) of carrageenan using KOH = 0.04, NaOH = 0.02, and Ca(OH) = 0.02. The brittle fracture index (BFI) of the carrageenan was KOH = 0.67, NaOH = 0.26, and Ca(OH) = 0.04. The order of carrageenan solubility in water was NaOH > KOH > Ca(OH). These data can be used as the basis for the development of carrageenan for excipients in solid dosage forms.

摘要

碱的类型和pH值对卡拉胶物理性质的影响已得到广泛研究。然而，它们对卡拉胶固态性质某些特征的影响尚未明确。本研究旨在探究碱性溶剂类型和pH值对从……分离出的卡拉胶固体物理性质的影响。使用NaOH、KOH和Ca(OH)在pH值为9、11和13的条件下从藻类中提取卡拉胶。基于包括产率、灰分含量、pH值、硫酸盐含量、粘度和凝胶强度在内的初步表征结果，发现所有样品均符合联合国粮食及农业组织（FAO）的规范。基于碱的类型，卡拉胶的溶胀能力为KOH > NaOH > Ca(OH)。所有样品的傅里叶变换红外光谱（FTIR）与标准卡拉胶的光谱一致。以KOH作为碱时，卡拉胶的分子量（MW）顺序为pH 13 > pH 9 > pH 11，以NaOH作为碱时，顺序为pH 9 > pH 13 > pH 11，以Ca(OH)作为碱时，顺序为pH 13 > pH 9 > pH 11。对每种碱中分子量最高的卡拉胶进行固态物理表征的结果表明，使用Ca(OH)的卡拉胶形态为立方体形且更像晶体。使用不同类型碱时卡拉胶的结晶度顺序为Ca(OH)（14.44%）> NaOH（9.80%）> KOH（7.91%），而密度顺序为Ca(OH) > KOH > NaOH。卡拉胶的固体分数（SF）顺序为KOH > Ca(OH) > NaOH，使用KOH时的拉伸强度为1.17，使用NaOH时为0.08，使用Ca(OH)时为0.05。使用KOH的卡拉胶的键合指数（BI）= 0.04，NaOH = 0.02，Ca(OH) = 0.02。卡拉胶的脆碎度指数（BFI）为KOH = 0.67，NaOH = 0.26，Ca(OH) = 0.04。卡拉胶在水中的溶解度顺序为NaOH > KOH > Ca(OH)。这些数据可作为开发用于固体剂型辅料的卡拉胶的依据。