Zhivkov Alexandar M, Popov Trifon T, Hristova Svetlana H
Institute of Physical Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 11, 1113 Sofia, Bulgaria.
Medical Faculty, Medical University-Sofia, Zdrave Str. 2, 1431 Sofia, Bulgaria.
Gels. 2023 May 17;9(5):421. doi: 10.3390/gels9050421.
Hydrogels have many useful physicochemical properties which, in combination with their biocompatibility, suggest their application as a drug delivery system for the local and prorogated release of drugs. However, their drug-absorption capacity is limited because of the gel net's poor adsorption of hydrophilic molecules and in particular, hydrophobic molecules. The absorption capacity of hydrogels can be increased with the incorporation of nanoparticles due to their huge surface area. In this review, composite hydrogels (physical, covalent and injectable) with included hydrophobic and hydrophilic nanoparticles are considered as suitable for use as carriers of anticancer chemotherapeutics. The main focus is given to the surface properties of the nanoparticles (hydrophilicity/hydrophobicity and surface electric charge) formed from metal and dielectric substances: metals (gold, silver), metal-oxides (iron, aluminum, titanium, zirconium), silicates (quartz) and carbon (graphene). The physicochemical properties of the nanoparticles are emphasized in order to assist researchers in choosing appropriate nanoparticles for the adsorption of drugs with hydrophilic and hydrophobic organic molecules.
水凝胶具有许多有用的物理化学性质，再加上它们的生物相容性，表明它们可用作药物递送系统，用于药物的局部和延长释放。然而，由于凝胶网络对亲水分子尤其是疏水分子的吸附性较差，它们的药物吸收能力有限。由于纳米颗粒具有巨大的表面积，因此通过掺入纳米颗粒可以提高水凝胶的吸收能力。在这篇综述中，包含疏水性和亲水性纳米颗粒的复合水凝胶（物理、共价和可注射）被认为适合用作抗癌化疗药物的载体。主要关注由金属和介电物质形成的纳米颗粒的表面性质（亲水性/疏水性和表面电荷）：金属（金、银）、金属氧化物（铁、铝、钛、锆）、硅酸盐（石英）和碳（石墨烯）。强调纳米颗粒的物理化学性质，以帮助研究人员选择合适的纳米颗粒来吸附具有亲水性和疏水性有机分子的药物。
