School of Traditional Chinese Medicine, Shenyang Medical College, Shenyang, Liaoning, China.
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.
Nat Prod Res. 2024 May;38(10):1687-1694. doi: 10.1080/14786419.2023.2217469. Epub 2023 May 26.
Bioassay-guided isolation of the stems of led to one new adamantane-type polycyclic polyprenylated acylphloroglucinols (PPAPs), (-)-garpauvinin A (), and four known analogues (). The structure and absolute configuration of was established spectroscopic techniques and ECD method. All the isolates displayed moderate antiproliferative activity against HL-60, PC-3 and Caco-2 human cancer cell lines with IC values ranging from 0.81 to 19.92 μM, and exhibited low toxicity on WPMY-1 normal human cells, showing selectivity between normal and malignant prostate cells. The biosynthetic pathways of the isolated PPAPs were proposed.
导向生物测定法从 led 的茎中分离得到一种新的金刚烷型多环多聚异戊烯基酰基间苯三酚（PPAPs），(-)-garpauvinin A ()，以及四种已知的类似物 ()。通过光谱技术和 ECD 方法确定了 的结构和绝对构型。所有分离出的化合物均表现出对 HL-60、PC-3 和 Caco-2 人癌细胞系的中等抗增殖活性，IC 值范围为 0.81 至 19.92 μM，并且对 WPMY-1 正常人类细胞的毒性较低，显示出正常和恶性前列腺细胞之间的选择性。提出了分离出的 PPAPs 的生物合成途径。
Zotero 插件