钩果金丝桃中具有金刚烷型结构的多环多聚异戊烯基酰基间苯三酚类化合物。
homo-Adamantane type polycyclic polyprenylated acylphloroglucinols from Hypericum hookerianum.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.
出版信息
Fitoterapia. 2019 Mar;133:43-50. doi: 10.1016/j.fitote.2018.12.014. Epub 2018 Dec 18.
Hookeriones I-Q (1-9), nine new homo-adamantane type polycyclic polyprenylated acylphloroglucinols (PPAPs), were isolated from Hypericum hookerianum, along with twenty known analogues. These structures were determined on the basis of comprehensive NMR and MS spectroscopic data. Comprehensive analysis of the NMR data revealed the correlations between the configuration of H-18 and H-28 and the chemical shifts of related signals. The cytotoxicity and anti-allergic activities of the new isolates were evaluated, and several ones exhibited moderate cytotoxicity against ECA-109 cell lines.
钩叶藤素 I-Q（1-9），9 个新的同金钢烷型多环聚异戊烯基酰基间苯三酚（PPAPs），从钩果藤中分离出来，同时分离出 20 个已知类似物。这些结构是基于全面的 NMR 和 MS 光谱数据确定的。全面分析 NMR 数据揭示了 H-18 和 H-28 的构型与相关信号的化学位移之间的相关性。对新分离物的细胞毒性和抗过敏活性进行了评估，其中几个对 ECA-109 细胞系表现出中等的细胞毒性。
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