Waxman J, Bose W J
J Rheumatol. 1986 Apr;13(2):408-11.
We report two patients with laryngeal manifestations of Wegener's granulomatosis to demonstrate the marked variability of presentation in this disease. The reported literature is reviewed and shows a similar spectrum with early and late onset of laryngeal granulomata, subglottic in location. Of all the patients with Wegener's granulomatosis reviewed, 8.5% will eventually develop a subglottic lesion. Therapy depends upon response to steroids, cytotoxic drugs, and radiation therapy. Usually surgical therapy will be necessary.
我们报告两例韦格纳肉芽肿病的喉部表现患者，以证明该疾病表现的显著变异性。对已发表的文献进行了回顾，结果显示其表现谱相似，喉部肉芽肿有早发和晚发情况，位于声门下。在所有经回顾的韦格纳肉芽肿病患者中，8.5%最终会出现声门下病变。治疗取决于对类固醇、细胞毒性药物和放射治疗的反应。通常需要手术治疗。
